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Apparatus and method of preparation for automated high output biopolymer crystallization via vapor diffusion sitting drop and micro-batch techniques

  • US 6,402,837 B1
  • Filed: 10/30/2000
  • Issued: 06/11/2002
  • Est. Priority Date: 10/30/2000
  • Status: Expired due to Fees
First Claim
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1. A robotic station for protein crystallization comprising:

  • (a) a magazine storing at least one empty microplate, (b) said microplate being comprised of an array of wells paired with reservoirs;

    (c) a nest that holds the microplate in position and indexes via an electrically or mechanically driven mechanism;

    (d) a mechanism for feeding a microplate into said nest;

    (e) a liquid dispensing system with at least one probe, each said probe containing at least one bore that delivers specified volumes into specific wells and reservoirs of said microplate;

    (f) an electrically or mechanically driven system that positions said probe over targeted reservoirs and wells;

    (g) a sealing mechanism that transfers a seal from a dispenser onto selected wells and reservoirs to seal them from the environment;

    (h) an incubator for storing the microplates in a controlled environment;

    (i) a microplate removing mechanism that removes a microplate from the nest and places it in said incubator;

    (j) a stacking mechanism that stacks the microplates inside said incubator.

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