Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
First Claim
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1. A method of noninvasive monitoring of glucose concentration in real time using laser optoacoustic imaging, comprising the steps of:
- irradiating a tissue of interest with at least one optical pulse to create a distribution of absorbed optical energy in said tissue;
generating an optothermally-induced pressure profile under conditions of temporal pressure confinement in the irradiated tissue;
detecting said pressure profile with at least one wide-band acoustic transducer, wherein said acoustic transducer is capable of detecting the entire range of ultrasonic frequencies contained in said pressure profile;
recording an amplitude and temporal profile of said pressure profile by an electronic system;
analyzing the ultrasonic frequency of said pressure profile, wherein a change in the ultrasonic frequency indicates a change in tissue scattering coefficient, which in turn is proportional to a change in glucose concentration in said tissue, which correlates with a change of glucose concentration in blood.
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Abstract
The present invention is directed to a method/system of monitoring in real time changes in concentration of glucose in tissues. Laser-induced profiles of absorbed optical energy distribution in tissues are determined via measurements of spatial (in-depth) profile of optically-induced acoustic (pressure) transients using a wide-band optoacoustic transducer. Such technique can be applied for monitoring of glucose concentration in various human or nonhuman tissues, cell cultures, solutions or emulsions.
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Citations
19 Claims
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1. A method of noninvasive monitoring of glucose concentration in real time using laser optoacoustic imaging, comprising the steps of:
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irradiating a tissue of interest with at least one optical pulse to create a distribution of absorbed optical energy in said tissue;
generating an optothermally-induced pressure profile under conditions of temporal pressure confinement in the irradiated tissue;
detecting said pressure profile with at least one wide-band acoustic transducer, wherein said acoustic transducer is capable of detecting the entire range of ultrasonic frequencies contained in said pressure profile;
recording an amplitude and temporal profile of said pressure profile by an electronic system;
analyzing the ultrasonic frequency of said pressure profile, wherein a change in the ultrasonic frequency indicates a change in tissue scattering coefficient, which in turn is proportional to a change in glucose concentration in said tissue, which correlates with a change of glucose concentration in blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system comprising:
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a pulsed optical source to produce a pressure profile confined in a volume of tissue of interest;
a light delivery system for delivery of radiation to said tissue;
at least one wide-band acoustic transducer operating in the frequency range of from 900 kHz to 200 MHz to detect the pressure profile in said tissue, wherein said acoustic transducer is capable of detecting the entire range of ultrasonic frequencies contained in the pressure profile; and
an electronic system for recording and processing of said detected pressure profile. - View Dependent Claims (17, 18, 19)
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Specification