Apparatus and method for vasodilation

• US 6,406,486 B1
• Filed: 12/15/1999
• Issued: 06/18/2002
• Est. Priority Date: 10/03/1991
• Status: Expired due to Fees

• Current Assignee: Pharmacopeia LLC (Ligand Pharmaceuticals, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Gregory, Kenton W., De La Torre, Ralph
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/461,996
• Time in Patent Office: 916 Days
• Field of Search: 601/2, 601/15, 606/2, 606/2.5, 606/3, 606/13-16, 606/128, 606/194, 607/88, 607/89, 600/437, 600/462
• US Class Current: 607/89
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/22022 using electric discharge
• CPC Class Codes: A61B 18/26 for producing a shock wave, e.g. laser lithotripsy
• CPC Class Codes: A61B 2017/22008 used or promoted

Abstract

A method and apparatus for dilating blood vessels in vasospasm through the use of high frequency wave, e.g., hydraulic or acoustic waves. The invention is suitable to treat any vasospasm, including any vasospasm intractable to medication, including cerebral vasospasm, which currently is not susceptible to any mechanical or chemical treatments. The apparatus for dilating blood vessels includes a catheter having a fluid-filled lumen, a wave generator arranged within the catheter lumen for generating a wave front that propagates through the fluid in the lumen and is transmitted from the distal end of the catheter to propagate through the fluid in the blood vessel, and an energy source connected to the wave generator to provide energy to produce the wave front.

Claims

1. A method of opening an occluded blood vessel, the method comprising the steps of:

inserting a catheter into the blood vessel, the catheter comprising a lumen that terminates at a distal end,

allowing a laser-energy absorptive fluid to enter the lumen,

providing laser energy to the laser-energy absorptive fluid in the lumen, the laser energy sufficient to displace a volume of the laser-energy absorptive fluid without causing laser-induced breakdown of the laser-energy absorptive fluid, and

allowing displacement of the volume of the laser-energy absorptive fluid to propagate beyond the distal end of the catheter and into the blood vessel to open the occluded blood vessel.

2. A method of opening an occluded blood vessel, the method comprising the steps of:

inserting a catheter into the blood vessel, the catheter comprising a lumen that terminates at a distal end,

allowing a laser-energy absorptive fluid to enter the lumen,

providing laser energy to the laser-energy absorptive fluid, the laser energy sufficient to displace a volume of the laser-energy absorptive fluid without producing a shock wave in the blood vessel beyond the distal end of the catheter, where that shock wave would otherwise be destructive to the blood vessel, and

allowing displacement of the volume of the laser-energy absorptive fluid to propagate beyond the distal end of the catheter and into the blood vessel to open the occluded blood vessel.

3. The method of claim 2, wherein the laser energy is provided in at least one pulse.

4. The method of claim 3, wherein a duration of the at least one pulse is from about 10 nanoseconds to about 300 microseconds.

5. The method of claim 2 or 3, wherein a wavelength of the laser energy is from less than about 600 nanometers.

6. The method of claim 2, wherein the laser energy is sufficient to avoid producing a shock wave in the blood vessel beyond the distal end of the catheter, where that shock wave would otherwise be destructive to the blood vessel.

7. An apparatus for opening an occluded blood vessel, comprising:

a catheter comprising a lumen that terminates at a distal end, and

a source of laser energy within the lumen for providing laser energy to a laser-energy absorptive fluid when the laser-energy absorptive fluid is present within the lumen, the laser energy sufficient to displace a volume of the laser-energy absorptive fluid without causing laser-induced breakdown thereof, such that the volume propagates beyond the distal end of the lumen and into the blood vessel to open the occluded blood vessel.

9. The apparatus of claim 7 or 8, wherein the laser energy is provided in at least one pulse.

10. The apparatus of claim 9, wherein a duration of the at least one pulse is from about 10 nanoseconds to about 300 microseconds.

11. The apparatus of claim 7 or 8, wherein a wavelength of the laser energy is from less than about 600 nanometers.

12. The apparatus of claim 7, wherein the laser energy is sufficient to avoid producing a shock wave in the blood vessel beyond the distal end of the catheter, where that shock wave would otherwise be destructive to the blood vessel.

8. An apparatus for opening an occluded blood vessel, comprising:

a catheter comprising a lumen that terminates at a distal end, and

a source of laser energy within the lumen for providing laser energy to a laser-energy absorptive fluid when the laser-energy absorptive fluid is present within the lumen, the laser energy sufficient to displace a volume of the laser-energy absorptive fluid without producing a shock wave in the blood vessel beyond the distal end of the lumen, where that shock wave would otherwise be destructive to the blood vessel, such that the volume propagates beyond the distal end of the lumen and into the blood vessel to open the occluded blood vessel.