Electroosmotic flow controlled microfluidic devices

• US 6,406,605 B1
• Filed: 05/08/2000
• Issued: 06/18/2002
• Est. Priority Date: 06/01/1999
• Status: Expired due to Term

• Current Assignee: YSI Incorporated (Xylem, Inc.)
• Original Assignee: YSI Incorporated (Xylem, Inc.)
• Inventors: Moles, Donald R.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Brown, Jennine M
• Application Number:
  US09/566,582
• Time in Patent Office: 771 Days
• Field of Search: 204/451, 204/452, 204/454, 204/600, 204/601, 422/100, 422/99, 251/129.04, 251/129.06, 251/66.1, 137/833, 137/825
• US Class Current: 204/601
• CPC Class Codes: F15C 5/00 Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
• CPC Class Codes: F16K 2099/008 Multi-layer fabrications
• CPC Class Codes: F16K 2099/0094 Micropumps
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0015 Diaphragm or membrane valves
• CPC Class Codes: F16K 99/0051 using electrostatic means
• CPC Class Codes: Y10T 137/2224 Structure of body of device

Abstract

In one embodiment, a fluidic module, such as a microfluidic module, has a fluid-flow channel, an electroosmotic flow membrane positioned in the channel, and a cathode located on one side and an anode located on the other side of the membrane so that an electrolyte in the channel is transported through the membrane in the presence of a voltage. In another embodiment, the channel has a port, a flexible and fluid-impermeable diaphragm is added, the electrolyte is contained in a reservoir, and the membrane moves the bladder which acts as a valve for fluid leaving the channel through the port. In a further embodiment, electrolyte in a first reservoir is transported through the membrane to move the bladder to force fluid out of a second reservoir.

Claims

1. A fluidic module comprising:

a) a fluid-flow channel having a port;

b) a diaphragm valve having;

(1) a flexible and fluid-impermeable diaphragm disposed in fluid communication with said port; and

(2) an electroosmotic-flow membrane having two sides and disposed contiguous with said diaphragm;

c) a reservoir containing an electrolyte in fluid communication with said membrane;

d) a cathode disposed on one of said two sides of said membrane; and

e) an anode disposed on the other of said two sides of said membrane such that, when a voltage is applied across said anode and said cathode, said electrolyte is transported through said membrane applying fluid pressure against said diaphragm flexibly moving said diaphragm relative to said port of said channel.

2. The fluidic module of claim 1, wherein said diaphragm flexibly moves against said port closing said valve when said voltage is applied across said anode and said cathode.

3. The fluidic module of claim 1, also including a pressurized fluid in said channel.

4. The fluidic module of claim 3, wherein said diaphragm flexibly moves against said port closing said valve from said pressurized fluid when said voltage is applied across said anode and said cathode.

5. The fluidic module of claim 4, wherein said pressurized fluid opens said valve when said voltage is reversed in sign and applied across said anode and said cathode.

6. A fluidic module comprising:

a) a first fluid-flow channel having a port;

b) a second fluid-flow channel having a port;

c) a surface area separating said ports of said first and second fluid-flow channels;

d) a diaphragm valve having;

(1) a flexible and fluid-impermeable diaphragm overlying said surface area and said ports of said first and second fluid-flow channels; and

(2) an electroosmotic-flow membrane having two sides and disposed contiguous with and overlying said diaphragm;

c) a reservoir containing an electrolyte in fluid communication with said membrane;

d) a cathode disposed on one of said two sides of said membrane; and

e) an anode disposed on the other of said two sides of said membrane such that, when a voltage is applied across said anode and said cathode, said electrolyte is transported through said membrane applying fluid pressure against said diaphragm flexibly moving said diaphragm against said surface area and said ports of said first and second fluid-flow channels closing said valve.

7. The fluidic module of claim 6, wherein said first and second fluid-flow channels each have a channel size of between about 50 microns and generally 500 microns.

8. The fluidic module of claim 6, wherein said membrane has a network of open pores each having a pore size of between about 30 angstroms and about 25 microns.

9. The fluidic module of claim 6, wherein said membrane has a thickness of between generally 2 microns and about 24 microns.

10. The fluidic module of claim 6, where electrolyte comprises water and wherein said effective voltage is less than about 2 volts.

11. A fluidic module comprising:

a) a fluid-flow channel;

b) an electroosmotic-flow membrane having two sides and disposed in said channel such that any fluid flow in said channel must pass through said membrane;

c) a cathode disposed on one of said two sides of said membrane; and

e) an anode disposed on the other of said two sides of said membrane such that, when said channel contains an electrolyte and a voltage is applied across said anode and said cathode, said electrolyte is transported through said membrane and, in the absence of said voltage, essentially none of said electrolyte is transported through said membrane.

12. The fluidic module of claim 11, wherein said channel contains an electrolyte and wherein, when said voltage is applied across said anode and said cathode, said electrolyte is transported through said membrane at a velocity which is dependent on the absolute value of said voltage.

13. The fluidic module of claim 11, wherein said first and second fluid-flow channels each have a channel size of between generally 50 microns and about 500 microns.

14. The fluidic module of claim 11, wherein said membrane has a network of open pores each having a pore size of between about 30 angstroms and about 25 microns.

15. The fluidic module of claim 11, wherein said membrane has a thickness of between about 2 microns and about 25 microns.

16. A fluid delivery system comprising:

a) a first reservoir containing an electrolyte;

b) a second reservoir having an outlet;

c) a flexible and fluid-impermeable diaphragm separating said first reservoir from said second reservoir;

d) an electroosmotic-flow membrane having two sides and disposed contiguous with said diaphragm and in fluid communication with said electrolyte;

e) a cathode disposed on one of said two sides of said membrane; and

f) an anode disposed on the other of said two sides of said membrane such that, when a fluid is disposed in said second reservoir and a voltage is applied across said anode and said cathode, said electrolyte is transported through said flow membrane applying fluid pressure against said diaphragm flexibly moving said diaphragm relative to said outlet forcing said fluid through said outlet of said second reservoir.

17. The fluid delivery system of claim 16, wherein said outlet has an outlet size of between about 50 microns and generally 500 microns.

18. The fluidic module of claim 16, wherein said membrane has a network of open pores each having a pore size of between about 30 angstroms and about 25 microns.

19. The fluidic module of claim 16, wherein said membrane has a thickness of between about 2 microns and about 25 microns.

20. The fluidic module of claim 16, wherein said effective voltage is less than about 2 volts.