Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby

• US 6,406,638 B1
• Filed: 01/06/2000
• Issued: 06/18/2002
• Est. Priority Date: 01/06/2000
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Stoeber, Boris, Liepmann, Dorian
• Primary Examiner(s): Gulakowski, Randy
• Assistant Examiner(s): Ahmed, Shamim
• Application Number:
  US09/478,913
• Time in Patent Office: 894 Days
• Field of Search: 216/2, 216/11, 216/49, 216/79, 438/712, 438/713, 438/719
• US Class Current: 216/11
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: B81B 1/006 Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters

Abstract

A method of forming a needle includes the step of anisotropically etching a channel into the back side of a semiconductor substrate. The front side of the semiconductor substrate is then isotropically etched to form a vertical axial surface surrounding the channel. The resultant needle has an elongated body formed of a semiconductor material. The elongated body includes an axial surface positioned between a first end and a second end. The axial surface defines a channel between the first end and the second end. In one embodiment, the first end has a sloping tip with a single circumferential termination point.

Claims

1. A method of forming a needle, said method comprising the steps of:

anisotropically etching a channel into the back side of a semiconductor substrate; and

isotropically etching the front side of said semiconductor substrate to form a vertical axial surface surrounding said channel, said vertical axial surface having a rounded cross-sectional profile between a tip of said needle and a base of said needle.

2. The method of claim 1 wherein said anisotropically etching step includes the step of deep reactive ion etching of said backside of said semiconductor substrate.

3. The method of claim 1 wherein said anisotropically etching step includes the step of forming a channel with a funnel region.

4. The method of claim 1 wherein said isotropically etching step includes the step of initially performing an anisotropic etch to alter a profile of said vertical axial surface.

5. The method of claim 1 wherein said isotropically etching step includes the step of deep reactive ion etching of said front side of said semiconductor substrate.

6. The method of claim 1 further comprising the step of depositing a protective material to cover an entire surface of said channel prior to said isotropically etching step.

7. A needle formed by the method of claim 1.

8. A method of forming a matrix of needles, said method comprising the steps of:

anisotropically etching channels into the back side of a semiconductor substrate; and

isotropically etching the front side of said semiconductor substrate to form vertical axial surfaces surrounding said channels, said vertical axial surfaces each having a rounded cross-sectional profile between a tip and a base of respective ones of said needles.

9. The method of claim 8 further comprising the step of cutting said semiconductor substrate to produce individual needles.

10. Needles formed by the method of claim 9.

11. The method of claim 8 further comprising step of utilizing said matrix of needles as a mold.

12. The method of claim 8 wherein said anisotropically etching step includes the step of anisotropically deep reactive ion etching.

13. A method of forming a needle, said method comprising the steps of:

anisotropically etching a channel into the back side of said semiconductor substrate with a channel mask;

isotropically etching the front side of said semiconductor substrate to form a vertical axial surface surrounding said channel with a needle mask, wherein said channel mask and said needle mask are offset by a predetermined distance such that a plane at which a surface of said channel and said vertical axial surface intersects is unparallel to said front side of said semiconductor substrate.

14. The method of claim 13 wherein said predetermined distance is smaller than a dimension of said channel.

15. The method of claim 13 wherein the vertical axial surface has a rounded cross-sectional profile between a tip of said needle and a base of said needle.

16. The method of claim 13 wherein said anisotropically etching step includes the step of forming a channel with a funnel region.

17. The method of claim 13 wherein said isotropically etching step includes the step of performing an anisotropic etch to alter a profile of said vertical axial surface.

18. The method of claim 13 wherein said isotropically etching step includes the step of deep reactive ion etching of said front side of said semiconductor substrate.

19. The method of claim 13 further comprising the step of depositing a protective material to cover an entirety of said surface of said channel prior to said isotropically etching step.

20. A needle formed by the method of claim 13.

21. A method of forming a needle comprising:

anisotropically etching a first side of a substrate to form a channel; and

isotropically etching a second side of the substrate to form a vertical axial surface surrounding the channel, wherein the first side is opposite to the second side.

22. The method of claim 21 wherein said channel is a close-ended channel.

23. The method of claim 22 further comprising etching the second side of the substrate to open the close-ended channel.

24. The method of claim 21 wherein the anisotropically etching step includes deep reactive ion etching of the first side of the substrate.

25. The method of claim 21 wherein the anisotropically etching step includes forming a channel with a funnel region.

26. The method of claim 21 wherein the channel extends from the first side to the second side of the substrate.

27. The method of claim 21 wherein the channel extends from the first side to a predetermined distance short of the second side of the substrate.

28. The method of claim 21 wherein the isotropically etching step includes initially performing an anisotropic etch to produce a steep vertical axial surface.

29. The method of claim 21 wherein the isotropically etching step includes deep reactive ion etching of the second side of the substrate.

30. The method of claim 21 wherein:

the anisotropically etching step is performed with a first mask having a first center and a first centerline passing through the first center,

the isotropically etching step is performed with a second mask having a second center and a second centerline passing through said second center, and

the first centerline is a predetermined distance from the second centerline.

31. The method of claim 22 further comprising depositing oxide to cover an entire surface of the channel prior to the isotropically etching step.

32. A needle formed by the method of claim 26.

33. A method of forming a matrix of needles comprising:

anisotropically etching a first side of a substrate to form a plurality of channels; and

isotropically etching a second side of the substrate to form a plurality of vertical axial surfaces, each of the plurality of vertical axial surfaces surrounding one of the plurality of channels,

wherein the first side is opposite to the second side.

34. The method of claim 33 wherein at least some of the plurality of channels are close-ended channels.

35. The method of claim 34 further comprising etching the second side of the substrate to open the close-ended channels.

36. The method of claim 33 further comprising cutting the substrate to produce individual needles.

37. Needles formed by the method of claim 36.

39. The method of claim 33 wherein the anisotropically etching step includes anisotropically deep reactive ion etching.

40. The method of claim 33 wherein the isotropically etching step includes isotropically deep reactive ion etching.

38. The method of 33 claim further comprising utilizing the matrix of needles as a mold.