Fatty acid treatment

• US 6,407,075 B1
• Filed: 07/06/1999
• Issued: 06/18/2002
• Est. Priority Date: 09/04/1996
• Status: Expired due to Fees

• Current Assignee: Luitpold Pharmaceuticals Incorporated (Daiichi Sankyo Company Limited)
• Original Assignee: Protarga, Inc.
• Inventors: Scott, Catherine A., Horrobin, David F.
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US09/254,286
• Time in Patent Office: 1,078 Days
• Field of Search: 514/34, 514/560
• US Class Current: 514/34
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

The use in preparation of a medicament for treating and preventing the side effects of anti-cancer chemotherapy of a polyunsaturated fatty acid with a carbon chain length of 14 to 26 and with 2 to 6 double bonds in the molecule in cis or trans configuration, and a method of such treatment or prevention wherein said fatty acid is used as an active.

Claims

1. A method of preventing or treating the side effects of anti-cancer chemotherapy selected from nausea, vomiting, suppression of the immune system, suppression of white blood cells and platelets, hair loss, cardiovascular damage, lung damage, renal damage, nerve damage or marked fatigue and malaise,

the method comprising administering to a subject in need thereof an enhanced effective amount of gamma-linolenic acid and an effective amount of doxorubicin.

2. A method of preventing or treating nausea or fatigue as side effects of anti-cancer chemotherapy comprising administering to a subject in need thereof an enhanced effective amount of gamma-linolenic acid and an effective amount of doxorubicin.