Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
DCFirst Claim
Patent Images
1. Pharmaceutical composition comprising an inclusion compound of (i) a drug capable of fitting into the cavity of the cyclodextrin ring system which is instable or only sparingly soluble in water with (ii) a partially etherified β
- -cyclodextrin of the formula;
0 Assignments
Litigations
0 Petitions
Reexamination
Accused Products
Abstract
Pharmaceutical compositions comprising inclusion compounds of sparingly water-soluble or water-instable drugs with β-cyclodextrin ethers or β-cyclodextrin esters and process for the preparation thereof.
-
Citations
35 Claims
-
1. Pharmaceutical composition comprising an inclusion compound of (i) a drug capable of fitting into the cavity of the cyclodextrin ring system which is instable or only sparingly soluble in water with (ii) a partially etherified β
- -cyclodextrin of the formula;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- -cyclodextrin of the formula;
-
12. Pharmaceutical composition comprising an inclusion compound of (i) a drug which is instable or only sparingly soluble in water and which is capable of fitting into the cavity of the β
- -cyclodextrin ring system and
(ii) a β
-cyclodextrin derivative of the formula;
- View Dependent Claims (13, 14, 15, 16, 17, 25, 26)
- -cyclodextrin ring system and
-
18. A method of producing a stabilizing amorphous complex of a drug and mixture of beta-cyclodextrin derivatives comprising the steps of:
-
(1) dissolving the intrinsically amorphous mixture of beta-cyclodextrin derivatives which are water soluble and capable of forming inclusion complexes with drugs in water, and (2) solubilizing sparingly water-soluble drugs into the aqueous media to form a solution and form a solubilized drug/cyclodextrin complex. - View Dependent Claims (19, 20, 23)
-
- 21. A composition of matter which contains a water-soluble amorphous complex of beta-cyclodextrin derivatives and a drug.
-
24. A composition of matter in solid form comprising progesterone as an inclusion complex with hydroxypropyl-beta-cyclodextrin adapted for administration by the oral route.
-
27. Pharmaceutical composition comprising an inclusion compound of (i) a drug capable of fitting into the cavity of the β
- -cyclodextrin ring system which is instable or only sparingly soluble in water and (ii) a partially etherified β
-cyclodextrin derivative of the formula;
- View Dependent Claims (28, 29, 30)
- -cyclodextrin ring system which is instable or only sparingly soluble in water and (ii) a partially etherified β
-
31. Pharmaceutical composition comprising an inclusion compound of (i) a drug capable of fitting into the cavity of the β
- -cyclodextrin ring system which is instable or only sparingly soluble in water and (ii) a partially etherified β
-cyclodextrin derivative of the formula;
- View Dependent Claims (32, 33, 34, 35)
- -cyclodextrin ring system which is instable or only sparingly soluble in water and (ii) a partially etherified β
Specification