Use of G class immunoglobulins for the topical treatment of atopic dermatitis

• US 6,410,019 B1
• Filed: 09/11/1997
• Issued: 06/25/2002
• Est. Priority Date: 03/14/1995
• Status: Expired due to Fees

• Current Assignee: VSL Pharmaceuticals, Inc.
• Original Assignee: Mendes S.U.R.L.
• Inventors: De Simone, Claudio, Bruschi, Pietro
• Primary Examiner(s): Caputa, Anthony C.
• Assistant Examiner(s): Canella, Karen A.
• Application Number:
  US08/913,339
• Time in Patent Office: 1,748 Days
• Field of Search: 530/387.1, 530/389.1, 530/868, 424/130.1, 424/141.1
• US Class Current: 424/130.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 16/06 from serum
• CPC Class Codes: Y10S 424/809 involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain

Abstract

The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly acne, contact dermatitis, atopic dermatitis, eczema and ichthyosis, psoriasis, papulosquamous dermatopathies (seborrehic dermatitis, erythrodermia, etc.), as well as fungus, parasite, bacterium and virus infection dermatitis is disclosed. The pharmaceutical composition containing G class immunoglobulins suitable for topical application for the treatment of dermatitis is also disclosed.

Claims

1. A method of treating the lesions of atopic dermatitis comprising topically administering to the atopic dermatitis lesions of a patient in need thereof an amount of G class immunoglobulin effective to treat the dermatitis and continuing topical application until the lesions disappear.

2. The method of claim 1 in which the G class immunoglobulin is in a topically applied solution, ointment, cream, gel or liposome.

3. The method of claim 1 in which in addition to the G class immunoglobulin also applied is an antibiotic agent, an antiviral agent, an antifungal agent, a vitamin, an anti-inflammatory, an antipyuretic, an antimicrobial, an usaturated fatty acid or an immunosuppressive agent.

4. The method of claim 1 in which a composition is topically applied in which the G class immunoglobulin is present in a concentration of from 0.1 to 25%.