Method of improving reproducibility of non-invasive measurements

• US 6,411,832 B1
• Filed: 12/16/1999
• Issued: 06/25/2002
• Est. Priority Date: 07/15/1992
• Status: Expired due to Fees

• Current Assignee: Optix LP
• Original Assignee: Optix LP
• Inventors: Guthermann, Howard E.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): Kremer, Matthew J
• Application Number:
  US09/465,105
• Time in Patent Office: 922 Days
• Field of Search: 600/309-310, 600/316, 600/322-324, 600/326, 600/328, 600/334-335, 600/340, 600/344, 356/39-41, 356/405, 250/343, 250/339
• US Class Current: 600/322
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: G01N 2021/3137 with selection of wavelengths after the sample
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method of improving the accuracy and reproducibility of non-invasive measurements of a concentration of a constituent of interest carried in a body part has been developed. The method relies on elevating the body part during the measurement cycle so that the body part is maintained above the heart during the measurement cycle. Measurements of the constituent during an arterial pulse leads to improved intra-run and run-to-tun determinations.

Claims

1. A method for minimizing variations in non-invasive measurements of concentration of a constituent of interest within a body part of a patient, said method comprising the steps of:

elevating said body part such that it remains at least 6 inches above the heart of the patient during the measurement cycle;

illuminating said body part with optical radiation;

measuring radiation transmitted, reflected or transflected from said body part;

calculating the concentration of said constituent of interest within said body part of said patient from the measured value of radiation.

2. The method of claim 1 further comprising the step of maintaining said body part elevated relative to the heart for a predetermined period of time prior to non-invasively measuring said concentration of said constituent of interest.

3. The method of claim 1 wherein optical radiation in said illuminating step comprises near infrared radiation and said measuring step utilizes a plurality of detectors, at least one of said detectors being selected to be sensitive to a portion of said infrared illuminating radiation.

4. The method of claim 3 wherein said illumination step comprises utilizing broad band illumination.

5. The method of claim 3 wherein said detection step comprises utilizing detectors arranged for congruent sampling.

6. The method of claim 1 wherein said at least a portion of said measurement step comprises taking measurements during an arterial pulse cycle and wherein multiple measurements are made during the same arterial pulse.

7. The method of claim 1 wherein said illumination step comprises utilizing multiple illumination sources and each source utilizes a coded signal upon its illuminating radiation.

8. The method of claim 1 wherein said illumination step comprises utilizing polarized illumination.

9. The method of claim 1 wherein said detection step comprises utilizing detectors having at least partial overlap in wavelength.

10. The method of claim 1 wherein said constituent of interest comprises glucose.

11. The method of claim 1 wherein said constituent of interest comprises hemoglobin.

12. The method of claim 1 wherein said body part comprises a finger.

13. The method of claim 1 wherein said body part is elevated at least 18 inches above the heart during the measurement cycle.