System for multiple site biphasic stimulation to revert ventricular arrhythmias

• US 6,411,845 B1
• Filed: 09/05/2000
• Issued: 06/25/2002
• Est. Priority Date: 03/04/1999
• Status: Expired due to Term

• Current Assignee: MR3 Medical, LLC
• Original Assignee: Mower Family Chf Treatment Irrevocable Trust
• Inventors: Mower, Morton M.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/654,995
• Time in Patent Office: 658 Days
• Field of Search: 607/4, 607/5, 607/14, 607/6, 607/7, 607/8, 607/9
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An anti-reentry apparatus and method for reverting ventricular arrhythmias. Biphasic stimulation is applied at multiple ventricular sites to revert arrhythmias caused by reentry, particularly multiple random reentry. In the preferred embodiment, the first phase of biphasic stimulation is anodal, and is at a maximum subthreshold amplitude. The anodal phase preconditions the myocardium to accept the second phase (cathodal) such that less electrical energy is required to reach the threshold amplitude to produce depolarization. The anodal phase stimulation may have a shape over time that is square wave, ramped, or a series of short square wave pulses. Multiple electrodes located at multiple ventricular sites may be stimulated simultaneously, or they may be sequentially stimulated over time in a manner mimicking the normal progress pattern of cardiac depolarization. The multiple ventricular electrodes may stimulate from internal or external surfaces. One or both ventricles may receive biphasic stimulation from multiple electrodes. The invention also may be practiced with respect to atria.

Claims

1. An apparatus for applying biphasic myocardial stimulation, the apparatus comprising:

at least two electrodes adapted to administer biphasic stimulation to myocardial tissue; and

a pacemaker connected to provide biphasic stimulation to the at least two electrodes, wherein the biphasic stimulation comprises;

a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration, so as to precondition the myocardium to accept subsequent stimulation, and

a second stimulation phase having a second phase polarity, a second phase amplitude that is larder in absolute value than the first phase amplitude, a second phase shape, and a second phase duration; and

wherein the pacemaker repeatedly provides biphasic stimulation so long as fibrillation is detected.

2. The apparatus for applying myocardial stimulation according to claim 1, wherein the first phase polarity is positive, and the second phase polarity is negative.

3. The apparatus for applying myocardial stimulation according to claim 2, wherein the first phase amplitude is at a maximum subthreshold amplitude.

4. The apparatus for applying myocardial stimulation according to claim 3, wherein the maximum subthreshold amplitude is about 0.5 volt to about 3.5 volts.

5. The apparatus for applying myocardial stimulation according to claim 1, wherein the first phase shape is ramped from a baseline value to a second value.

6. The apparatus for applying myocardial stimulation according to claim 5, wherein the second value is not more than a maximum subthreshold amplitude.

7. The apparatus for applying myocardial stimulation according to claim 1, wherein the first phase duration is about one millisecond to about nine milliseconds.

8. The apparatus for applying myocardial stimulation according to claim 1, wherein the second phase amplitude is about two volts to about twenty volts.

9. The apparatus for applying myocardial stimulation according to claim 1, wherein the second phase duration is about 0.2 millisecond to about 1.5 milliseconds.

10. The apparatus for applying myocardial stimulation according to claim 1, wherein the first stimulation phase further comprises a series of stimulating pulses of a predetermined amplitude and duration, and a series of rest periods.

11. The apparatus for applying myocardial stimulation according to claim 10, wherein applying the first stimulation phase further comprises applying a rest period after at least one stimulating pulse.

12. The apparatus for applying myocardial stimulation according to claim 10, wherein the predetermined duration is about 0.2 millisecond to about 1.5 milliseconds.

13. The apparatus for applying myocardial stimulation according to claim 10, wherein the rest period is about 0.2 millisecond to about 1.2 milliseconds.

14. The apparatus for applying myocardial stimulation according to claim 1, wherein the first phase shape is selected from the group consisting of:

square wave pulse, ramped pulse, and series of short duration square wave pulses.

15. The apparatus for applying myocardial stimulation according to claim 1, wherein at least one of the electrodes is adapted for application to an inner ventricular wall via the vena cava.

16. The apparatus for applying myocardial stimulation according to claim 1, wherein at least one of the electrodes is adapted for application to an exterior ventricular wall.

17. The apparatus for applying myocardial stimulation according to claim 1, wherein the stimulation is applied to the electrodes progressively in a manner that mimics the normal flow of electrical depolarization in a heart.

18. The apparatus for applying myocardial stimulation according to claim 17,

wherein the electrodes closest to the A-V node are the first to administer stimulation,

wherein the electrodes farthest from the A-V node, following the normal intrinsic conduction paths, are the last to administer stimulation; and

wherein the electrodes intermediate between the electrodes closest to the A-V node and the electrodes farthest from the A-V node each administer stimulation at an intermediate time that is proportional to their intermediate position, following the normal intrinsic conduction paths.

19. The apparatus for applying myocardial stimulation according to claim 18, wherein the electrodes are ordered by class according to their distance from the A-V node, following the normal intrinsic conduction paths.

20. The apparatus for applying myocardial stimulation according to claim 19, wherein the number of classes is between two and about thirty.

21. The apparatus for applying myocardial stimulation according to claim 1, wherein the first stimulation phase comprises an anodal stimulus.

22. A cardiac stimulation apparatus for reverting ventricular arrhythmias with biphasic waveforms, the apparatus comprising:

at least two electrodes adapted to administer biphasic stimulation to cardiac tissue, wherein the biphasic stimulation comprises;

a first stimulation phase having a positive polarity, a subthreshold amplitude, a duration of about one millisecond to about nine milliseconds, and a shape, wherein the shape is selected from the group consisting of;

square wave pulse, ramped pulse, and series of short duration square wave pulses; and

a second stimulation phase having a negative polarity, an amplitude of about two volts to about twenty volts that is larger in absolute value than the first stimulation chase subthreshold amplitude, and a duration of about 0.2 millisecond to about 1.5 milliseconds.