Apparatus for applying cyclic pacing at an average rate just above the intrinsic heart rate
First Claim
1. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
- plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as biphasic pacing stimuli, wherein the biphasic stimulation comprises an anodal stimulation phase followed by a cathodal stimulation phase;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, and wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate.
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Abstract
Apparatus for cyclic ventricular pacing starting at a rate just above the intrinsic atrial firing rate (overdrive pacing), followed by relaxation to a rate just below the intrinsic atrial firing rate (ventricular escape). The method and apparatus can be applied to one or both ventricles, and can utilize one or more electrodes per ventricle. The electrode(s) can be applied to inner or outer ventricular surfaces. Relaxation protocols as a function of time can be linear, curvilinear to include exponential, or mixtures thereof. Furthermore, relaxation protocols can include one or more periods of time during which the pacing rate is held constant. Typically, the average ventricular pacing rate using this invention will be slightly greater than the intrinsic atrial firing rate, though alternate embodiments that encompass average ventricular pacing rates that are equal to or slightly less than the intrinsic atrial firing rate are also envisioned. Application of this method and apparatus to a heart in need thereof will produce a heart with an optimally minimized energy output requirement.
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Citations
27 Claims
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1. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as biphasic pacing stimuli, wherein the biphasic stimulation comprises an anodal stimulation phase followed by a cathodal stimulation phase;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, and wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
physiological parameter sensor circuitry to determine if additional cardiac pacing is needed.
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3. The cardiac stimulator to perform cardiac pacing according to claim 2, wherein the physiological parameters are selected from the group consisting of:
- A-V interval, atrial entrainment of left and right ventricles, length of QRS complex, magnitude of QRS complex, arterial blood pressure, venous blood pressure, heart rate, ventricular fibrillation, atrial fibrillation, and probability density function.
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4. The cardiac stimulator to perform cardiac pacing according to claim 1, wherein applying the pacing stimuli and decreasing the pacing rate is repeated in a cyclic pattern.
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5. The cardiac stimulator to perform cardiac pacing according to claim 1, wherein a protocol for decreasing the pacing rate over time is selected from the group consisting of:
- linear, curvilinear, exponential, and combinations thereof.
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6. The cardiac stimulator to perform cardiac pacing according to claim 5, wherein the protocol for decreasing the pacing rate includes one or more periods of time in which the pacing rate is held constant.
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7. The cardiac stimulator to perform cardiac pacing according to claim 1, wherein the pacing stimuli are selected from the group consisting of:
- monophasic stimulation and biphasic stimulation.
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8. The cardiac stimulator to perform cardiac pacing according to claim 7, wherein the monophasic stimulation is selected from the group consisting of:
- cathodal stimulation and anodal stimulation.
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9. The cardiac stimulator to perform cardiac pacing according to claim 1, wherein the anodal stimulation phase has a magnitude equal to or less than a maximum subthreshold amplitude;
- and has an approximate shape selected from the group consisting of;
square wave, increasing ramp, and series of short duration square waves.
- and has an approximate shape selected from the group consisting of;
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10. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate, and wherein a protocol for decreasing the pacing rate includes one or more periods of time in which the pacing rate is held constant.
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11. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate, and wherein the initial pacing rate minus the intrinsic atrial firing rate is greater than the intrinsic atrial firing rate minus the minimum pacing rate.
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12. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate, and wherein the initial pacing rate minus the intrinsic atrial firing rate is equal to the intrinsic atrial firing rate minus the minimum pacing rate.
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13. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than she intrinsic atrial firing rate, and wherein the initial pacing rate minus the intrinsic atrial firing rate is less than the intrinsic atrial firing rate minus the minimum pacing rate.
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14. An implantable cardiac stimulator to perform pacing of a heart, the heart having an intrinsic atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the intrinsic atrial firing rate, wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate, and wherein the pacing stimuli are applied via multiple electrodes to at least one ventricle.
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15. An implantable cardiac stimulator to perform pacing of a heart, the heart having a paced atrial firing rate, the cardiac stimulator comprising:
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plural electrodes adapted to applying pacing stimuli to the heart; and
pulse generating circuitry connected to the plural electrodes and adapted to generate electrical pulses as pacing stimuli;
wherein a series of pacing stimuli are applied to at least one ventricle having an initial pacing rate, the initial pacing rate being slightly greater than the paced atrial firing rate, and wherein the pacing rate is decreased over time from the initial pacing rate to a minimum pacing rate that is slightly less than the paced atrial firing rate. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification