Method of determining a ventilatory threshold breakpoint for an adaptive rate pacemaker

• US 6,411,850 B1
• Filed: 09/30/1999
• Issued: 06/25/2002
• Est. Priority Date: 09/30/1999
• Status: Expired due to Fees

• Current Assignee: UAB Research Foundation (University of Alabama System)
• Original Assignee: UAB Research Foundation (University of Alabama System)
• Inventors: Hopper, Donald L., Hall, Jeff, Heemells, Jan-Pieter, Kay, G. Neal
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US09/408,623
• Time in Patent Office: 999 Days
• Field of Search: 607/17-20, 607/9, 600/534-536, 600/547
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A method for automatically determining the ventilatory (or “anaerobic”) threshold breakpoint for adaptive rate pacing without the need for directly measuring anaerobic threshold or ventilatory threshold comprises: (a) positioning a first sensing electrode in the heart or superior vena cava of a patient carrying an implanted pacemaker, the first sensing electrode connected to the implanted pacemaker; (b) positioning a second sensing electrode in the thoracic region of the patient and spaced apart from the first sensing electrode; (c) determining the chest wall impedance of the patient between the first sensing electrode and the second sensing electrode; (d) measuring the ventilation (e.g., the minute ventilation) of the subject from the chest wall impedance during submaximal exercise by the patient; and then (e) determining the ventilatory threshold breakpoint of the patient from the measured ventilation. In the pacemaker, the adaptive rate pacing is preferably based on measured chest wall impedance, with pacing rate increasing as exercise or metabolic activity sensed thereby increases. The implanted pacemaker is then preferably programmed, preferably automatically, so that the rate of increase in pacing rate in response to increasing ventilation by the pacemaker is attenuated after the breakpoint is reached. Peak ventilation is preferably also determined so that the maximum pacing rate of the pacemaker output is matched to the peak ventilation during adaptive rate pacing from the pacemaker. Apparatus implementing the method is also disclosed.

Claims

1. A method for automatically determining the ventilatory threshold breakpoint for adaptive rate pacing without the need for directly measuring anaerobic threshold or ventilatory threshold in a human patient carrying an implanted pacemaker, said method comprising:

positioning a first sensing electrode in the heart or superior vena cava of said patient, said first sensing electrode connected to said implanted pacemaker;

positioning a second sensing electrode in the thoracic region of said patient and spaced apart from said first sensing electrode;

determining the chest wall impedance of said patient between said first sensing electrode and said second sensing electrode;

then

measuring the ventilation of said subject from said chest wall impedance during submaximal exercise by said patient; and

then

determining the ventilatory threshold breakpoint of said patient from said measured ventilation;

wherein said determining step is carried out by calculating a parameter from said measured ventilation, said parameter selected from the group consisting of respiratory rate change during submaximal exercise, tidal volume change during submaximal exercise, and tidal volume during steady state submaximal exercise, and then determining said ventilatory threshold breakpoint from said calculated parameter.

2. A method according to claim 1, wherein said second sensing electrode is positioned outside the pleural cavity of said patient.

3. A method according to claim 1, wherein said second sensing electrode is positioned on the surface of said implanted pacemaker.

4. A method according to claim 1, wherein said step of measuring the ventilation of said subject is carried out by measuring the minute ventilation (VE) of said subject.

5. A method according to claim 1, further comprising the step of:

measuring respiratory rate (RR) concurrently with said step of measuring the ventilation of said subject;

and wherein said determining step comprises determining the ventilatory threshold breakpoint of said patient from both said measured ventilation during submaximal exercise and said measured respiratory rate during submaximal exercise.

6. A method according to claim 5, further comprising the steps of:

determining the onset slope of tidal volume (V_t) during said submaximal exercise;

determining the onset slope of respiratory rate (RR) during said submaximal exercise;

determining the steady state of V_t during said submaximal exercise;

determining the steady state of RR during said submaximal exercise;

determining minute ventilation (VE) during a rest period prior to or following said submaximal exercise;

and wherein said determining step comprises determining the ventilatory threshold breakpoint of said patient from all of said measured ventilation during submaximal exercise;

said measured respiratory rate;

the onset slope of tidal volume during said submaximal exercise;

the onset slope of respiratory rate, the steady state of V_t during submaximal exercise; and

the steady state of RR during said submaximal exercise;

VE during said submaximal exercise; and

VE during said rest period.

7. A method according to claim 1, wherein said measuring step is initiated by operator control.

8. A method according to claim 1, wherein said step of determining the ventilatory threshold breakpoint is followed by the step of programming said pacemaker to reduce the rate of increase of the pacing rate at said determined ventilatory threshold.

9. A method according to claim 1, further comprising the step of determining the peak ventilation of said patient from said measured ventilation.

10. A method according to claim 9, further comprising the step of programming said pacemaker to match the maximum pacing rate of said pacemaker to said peak ventilation.

11. A method according to claim 10, wherein said programming step is carried out automatically without operator intervention.

12. A method for automatically matching the pacing rate of an adaptive rate pacemaker to the ventilatory threshold breakpoint and peak ventilation in a human subject carrying an implanted adaptive rate pacemaker without the need for a maximum exercise test on said subject, said method comprising:

positioning a first sensing electrode in the heart or superior vena cava of said patient, said first sensing electrode connected to said implanted pacemaker;

positioning a second sensing electrode in the thoracic region of said patient and spaced apart from said first sensing electrode;

determining the chest wall impedance of said patient between said first sensing electrode and said second sensing electrode;

measuring the ventilation of said subject from said chest wall impedance during submaximal exercise by said patient; and

then

calculating at least one parameter from said measured ventilation, said at least one parameter selected from the group consisting of respiratory rate change during submaximal exercise, tidal volume change during submaximal exercise, and tidal volume during steady state submaximal exercise; and

then

determining said ventilatory threshold breakpoint and said peak ventilation from said at least one calculated parameter;

then

programming said pacemaker to reduce the rate of increase of the pacing rate at said determined ventilatory threshold; and

programming said pacemaker to match the maximum pacing rate of said pacemaker to said peak ventilation.

13. A method according to claim 12, wherein said second sensing electrode is positioned outside the pleural cavity of said patient.

14. A method according to claim 12, wherein said second sensing electrode is positioned on the surface of said implanted pacemaker.

15. A method according to claim 12, wherein said measuring step is initiated by operator control.

16. A method according to claim 12, wherein said programming steps are carried out automatically without operator intervention.

17. A rate-responsive cardiac pacemaker, comprising:

pacing means for pacing a patient'"'"'s heart as a function of a pacing signal at a pacing rate up to a maximum pacing rate;

sensing means for sensing ventilation by said patient; and

control means operatively associated to said sensing means for determining a ventilatory threshold break point from said sensed ventilation;

said control means further determining a peak ventilation in response to said sensed ventilation.

18. A pacemaker according to claim 17, said sensing means comprising a chest wall impedance sensor.

19. A pacemaker according to claim 17;

said control means including means for modifying said pacing rate in response to said ventilatory threshold break point.

20. A pacemaker according to claim 17, said control means including means for matching said sensed ventilation to said maximum pacing rate.

21. A pacemaker according to claim 17, wherein said sensed ventilation is submaximal exercise sensed ventilation.