Method and assembly for performing ultrasound surgery using cavitation

• US 6,413,216 B1
• Filed: 12/22/1999
• Issued: 07/02/2002
• Est. Priority Date: 12/22/1998
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Fowlkes, J. Brian, Cain, Charles A.
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): QADERI, RUNA S
• Application Number:
  US09/470,644
• Time in Patent Office: 923 Days
• Field of Search: 600/439, 601/2, 601/24, 604/22, 424/450, 424/9.5, 424/9.51, 424/9.52
• US Class Current: 600/439
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method and assembly are provided which use cavitation induced by an ultrasound beam for creating a controlled surgical lesion in a selected treatment volume of a patient, such as an internal body cavity or organ. First, a plurality of microbubbles are provided in the treatment volume. Preferably, the threshold for cavitation of microbubbles in the treatment volume is lowered compared with the threshold for cavitation in surrounding tissues. The expected location of the surgical lesion within the treatment volume may be previewed, and then the microbubbles in the treatment volume are cavitated with the ultrasound beam to create the controlled surgical lesion. In addition, substances can be associated with the microbubbles such that cavitation of the microbubbles delivers the substances to the treatment volume. Preferably, the creation of the surgical lesion at the expected lesion location is then verified. Using the method and assembly of the present invention, the cavitation threshold within the treatment volume is made predictable, and a low frequency ultrasound beam may be used to cavitate the microbubbles within the treatment volume without causing damage to surrounding tissues.

Claims

1. A method for delivering substances to a selected treatment volume of a patient, the method comprising:

providing a plurality of microbubbles in the treatment volume, wherein the microbubbles are associated with the substances to be delivered;

expanding the treatment volume to fully admit the microbubbles therein; and

cavitating the plurality of microbubbles with an ultrasound beam of sufficient energy at an appropriate frequency to deliver the substances in a controlled manner within the treatment volume.

2. The method of claim 1, wherein the treatment volume includes an internal body surface.

3. The method of claim 1, wherein the frequency of the ultrasound beam is a low frequency.

4. The method of claim 1, wherein the microbubbles have a threshold for cavitation, and wherein the method further comprises lowering the threshold for cavitation of the microbubbles in the treatment volume compared with the threshold for cavitation of microbubbles in a volume external to the treatment volume.

5. The method of claim 4, wherein lowering the threshold for cavitation of microbubbles in the treatment volume comprises producing a population of microbubbles within the treatment volume which have a limited size distribution, so that the microbubbles oscillate at a maximal response frequency.

6. The method of claim 4, wherein lowering the threshold for cavitation of microbubbles in the treatment volume comprises eliminating microbubbles from the external volume with a low intensity ultrasound beam.

7. The method of claim 1, wherein providing the plurality of microbubbles includes injecting the microbubbles into the patient systemically.

8. The method of claim 1, wherein providing the plurality of microbubbles includes injecting the microbubbles locally into the treatment volume.

9. The method of claim 1, further comprising detecting the presence of microbubbles in the treatment volume.

10. The method of claim 1 wherein the ultrasound beam is focused.

11. The method of claim 1, wherein the ultrasound beam is unfocused.

12. The method of claim 1, wherein cavitating the microbubbles disrupts cell membranes in the treatment volume, thereby enhancing the uptake of the delivered substances.

13. The method of claim 1, wherein the substances are encapsulated within the microbubbles, such that cavitating the microbubbles releases the substances into the treatment volume.

14. The method of claim 1, wherein the microbubbles are conjugated to the substances.

15. The method of claim 1, wherein the substances are provided in an admixture with the microbubbles.

16. The method of claim 1, wherein the substances include one of drugs and DNA.

17. An ultrasound assembly for delivering substances to a selected treatment volume of a patient, the assembly comprising:

means for providing a plurality of microbubbles in the treatment volume, wherein the microbubbles are associated with the substances to be delivered;

means for expanding the treatment volume to fully admit the microbubbles therein;

a therapeutic transducer for generating and directing an ultrasound beam of energy in the treatment volume; and

a controller for controlling the transducer so that the transducer generates and directs the ultrasound beam of sufficient energy at an appropriate frequency to deliver the substances in a controlled manner within the treatment volume.

18. The assembly of claim 17, wherein the treatment volume includes an internal body surface.

19. The ultrasound assembly of claim 17, wherein the frequency of the ultrasound beam is a low frequency.

20. The ultrasound assembly of claim 17, wherein the controller controls the therapeutic transducer to lower the threshold for cavitation of microbubbles in the treatment volume compared with the threshold for cavitation of microbubbles in a volume external to the treatment volume.

21. The ultrasound assembly of claim 17, wherein the ultrasound beam is focused.

22. The ultrasound assembly of claim 17, wherein the ultrasound beam is unfocused.

23. The ultrasound assembly of claim 17, wherein the therapeutic transducer comprises a plurality of transducer elements which form a phased array.

24. The ultrasound assembly of claim 17, wherein the therapeutic transducer is external to the body.

25. The ultrasound assembly of claim 17, wherein the therapeutic transducer is internal to the body.

26. The ultrasound assembly of claim 17, further comprising a diagnostic ultrasound system for providing images of the treatment volume.

27. The ultrasound assembly of claim 17, wherein the substances are encapsulated within the microbubbles.

28. The ultrasound assembly of claim 17, wherein the microbubbles are conjugated to the substances.

29. The ultrasound assembly of claim 17, wherein the substances are provided in an admixture with the microbubbles.

30. The ultrasound assembly of claim 17, wherein the substances include one of drugs and DNA.

31. A method for creating a surgical lesion in a selected treatment volume of a patient, the method comprising:

injecting a plurality of microbubbles in the treatment volume;

expanding the treatment volume to fully admit the microbubbles therein; and

cavitating the plurality of microbubbles with an ultrasound beam of sufficient energy at an appropriate frequency to create the surgical lesion in a controlled manner within the treatment volume.

32. The method of claim 31, wherein the treatment volume includes an internal body surface.

33. An ultrasound assembly for creating a surgical lesion in a selected treatment volume of a patient, the assembly comprising:

means for injecting a plurality of microbubbles in the treatment volume;

means for expanding the treatment volume to fully admit the microbubbles therein;

a therapeutic transducer for generating and directing an ultrasound beam of energy in the treatment volume; and

a controller for controlling the transducer so that the transducer generates and directs the ultrasound beam of sufficient energy at an appropriate frequency to create the surgical lesion in a controlled manner within the treatment volume.

34. The assembly of claim 33, wherein the treatment volume includes an internal body surface.

35. A method for delivering substances to a selected treatment volume of a patient, the method comprising:

providing a plurality of microbubbles in the treatment volume and in a volume external to the treatment volume, wherein the microbubbles are associated with the substances to be delivered, the microbubbles having a threshold for cavitation;

controlling the microbubbles in the external volume to create a differential threshold for cavitation between the external volume and the treatment volume; and

cavitating the plurality of microbubbles in the treatment volume with an ultrasound beam of sufficient energy at an appropriate frequency to deliver the substances in a controlled manner within the treatment volume.

36. The method of claim 35, wherein the treatment volume includes an internal body surface.

37. The method of claim 35, wherein the frequency of the ultrasound beam is a low frequency.

38. The method of claim 35, further comprising lowering the threshold for cavitation of microbubbles in the treatment volume by producing a population of microbubbles within the treatment volume which have a limited size distribution, so that the microbubbles oscillate at a maximal response frequency.

39. The method of claim 35, wherein controlling the microbubbles in the external volume includes reducing the cavitation potential in the external volume compared with the treatment volume.

40. The method of claim 39, wherein reducing the cavitation potential in the external volume comprises eliminating microbubbles from the external volume with a low intensity ultrasound beam.

41. The method of claim 35, further comprising expanding the treatment volume to fully admit the microbubbles therein.

42. The method of claim 35, wherein the substances are encapsulated within the microbubbles, such that cavitating the microbubbles releases the substances into the treatment volume.

43. The method of claim 35, wherein the microbubbles are conjugated to the substances.

44. The method of claim 35, wherein the substances are provided in an admixture with the microbubbles.