Sensor including UV-absorbing polymer and method of manufacture
First Claim
Patent Images
1. An implantable sensor comprising at least one functional coating layer, wherein the functional coating layer includes a UV-absorbing polymer and is biocompatible with human and animal tissue and fluids surrounding the human and animal tissue;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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Abstract
A sensor is provided that includes at least one functional coating layer that includes a UV-absorbing polymer. Methods for making the inventive sensors are also provided.
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Citations
51 Claims
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1. An implantable sensor comprising at least one functional coating layer, wherein the functional coating layer includes a UV-absorbing polymer and is biocompatible with human and animal tissue and fluids surrounding the human and animal tissue;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
- View Dependent Claims (2, 3, 4)
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5. A sensor comprising at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer selected from at least a polyurethane, a polyurea, a polyurethane/polyurea copolymer, polymethacrylate, polyacrylic acid, polycarbonate, and mixtures of these polymers and wherein said polymer is formed from a reaction mixture comprising a diisocyanate, at least one selected from the group consisting of a diol, a diamine and mixtures thereof, and a polyfunctional UV-absorbing monomer.
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6. A sensor comprising a plurality of functional coating layers each of which comprises a UV-absorbing polymer.
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7. A sensor comprising at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer, the sensor being substantially planar and further including a base layer, a cover layer and a sensor element disposed between said base and cover layers, wherein said cover layer has defined therein at least one opening above at least a portion of said sensor element and said base layer is comprised of a flexible material;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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8. A sensor comprising at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer, the sensor being substantially cylindrical and further including a base layer, a cover layer and a sensor element disposed between said base and cover layers, wherein said cover layer has defined therein at least one opening above at least a portion of said sensor element and said base layer is comprised of a flexible material;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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9. A sensor comprising at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer, the sensor further including a base layer, a cover layer and a conductive sensor element disposed between the base and cover layers, wherein the cover layer has defined therein at least one opening above at least a portion of the sensor element and wherein an enzyme is disposed in said opening;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
- View Dependent Claims (10, 11)
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12. A sensor comprising at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer, the sensor further including a base layer, a cover layer and a sensor element disposed between the base and cover layers, wherein said cover layer has defined therein a plurality of openings with at least one opening being above at least a portion of the sensor element;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
- View Dependent Claims (13, 14, 15)
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16. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least one functional coating layer, wherein said functional coating layer comprises a UV-absorbing polymer and is biocompatible; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.- View Dependent Claims (17)
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18. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least functional coating layer wherein said functional coating layer comprise a UV-absorbing polymer and is a polyurethane, a polyurea or a polyurethane/polyurea copolymer; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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19. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least functional coating layer wherein said functional coating layer comprise a UV-absorbing polymer having a UV absorption of at least 0.3 AU based on a thickness of 4 mm at at least one wavelength between 400 nm and 100 nm; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.- View Dependent Claims (20)
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21. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least functional coating layer wherein said functional coating layer comprise a UV-absorbing polymer formed from a reaction mixture comprising a diisocyanate, at least one selected from the group consisting of a diol, a diamine and mixtures thereof, and a polyfunctional UV-absorbing monomer.
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22. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least one functional coating layer, wherein said functional coaring layer comprises a UV-absorbing polymer and is selected from the group consisting of an analyte limiting layer, a biocompatible layer, a layer that increases the slipperiness of said sensor, a layer that promotes cellular attachment to said sensor and a layer that reduces cellular attachment to said sensor; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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23. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least two functional coating layers, each of which comprises a UV-absorbing polymer.
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24. A sensor comprising:
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a) a base layer comprised of a polyimide, b) a sensor element disposed on said base layer, c) a cover layer coveting said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least two functional coating layers wherein said functional coating layers comprise a UV-absorbing polymer.
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25. A sensor comprising:
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a) a base layer, b) a sensor element disposed on said base layer, c) a cover layer covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least two functional coating layers wherein said functional coating layers comprise a UV-absorbing polymer, wherein said cover layer is comprised of an insulative material.
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26. A sensor comprising:
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a) a base layer comprised of a polyimide, b) a sensor element disposed on said base layer, c) a cover layer comprised of an insulative material and covering said sensor element and having defined therein at least one opening above at least a portion of said sensor element, and d) at least two functional coating layers wherein said functional coating layers comprise a UV-absorbing polymer.
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27. A method of making a sensor comprising forming a functional coating layer from a UV-absorbing polymer, wherein the UV-absorbing polymer is biocompatible;
- and wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
- View Dependent Claims (28, 29)
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30. A method of making a sensor comprising forming at least two functional coating layers, each of said coating layers being formed from a UV-absorbing polymer.
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31. A method of making a sensor comprising:
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a) forming a base layer;
b) forming a sensor element on the base layer;
c) forming a cover layer covering the sensor element and at least a portion of the base layer;
d) defining at least one opening in the cover layer above at least a portion of the sensor element; and
e) forming a least one functional coating layer on the cover layer, wherein the functional coating layer includes a UV-absorbing polymer and is biocompatible; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.- View Dependent Claims (32)
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33. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising UV-absorbing polymer, wherein said UV-absorbing polymer is a polyurethane, a polyurea or a polyurethane/polyurea copolymer; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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34. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising UV-absorbing polymer, wherein said UV-absorbing polymer has a UV-absorption of at least 0.3 AU based on a thickness of 4 mm at at least one wavelength between 400 nm and 100 nm; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.- View Dependent Claims (35)
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36. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising UV-absorbing polymer, wherein said UV-absorbing polymer is formed from a reaction mixture comprising a diisocyanate, at least one selected from the group consisting of a diol, a diamine and mixtures thereof, and a polyfunctional UV-absorbing monomer.
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37. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising UV-absorbing polymer, wherein said functional coating layer is selected from the group consisting of an analyte limiting layer, a biocompatible layer, a layer that increases the slipperiness of said sensor, a layer that promotes cellular attachment to said sensor and a layer that reduces cellular attachment to said sensor; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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38. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least two functional coating layers on said cover layer, said at least two functional coating layers comprising a UV-absorbing polymer.
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39. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layers on said cover layer, said functional coating layer comprising UV-absorbing polymer, wherein said sensor element is a conductive sensor element that is formed on said base layer; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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40. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising a UV-absorbing polymer, wherein said sensor element is formed by depositing on said base layer at least one material that is reactive with a preselected analyte; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.
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41. A method of making a sensor comprising the steps of:
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a) forming a base layer, b) forming a sensor element on said base layer, c) forming a cover layer covering said sensor element and at least a portion of said base layer, d) defining at least one opening in said cover layer above at least a portion of said sensor element, and e) forming at least one functional coating layer on said cover layer, said functional coating layer comprising a UV-absorbing polymer, wherein at least two sensor elements are formed on said base layer prior to forming said cover layer; and
wherein the UV-absorbing polymer absorbs radiation in substantially the same range as an underlying layer.- View Dependent Claims (42, 43, 44)
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- 45. A sensor comprising a base layer and at least one functional coating layer over at least a portion of the base layer, wherein said functional coating layer comprises a UV-absorbing polymer that absorbs radiation in substantially the same range as the base layer.
Specification