Process and device for separation with variable-length chromatographic
First Claim
1. A non-simulated-moving-bed (non SMB) apparatus for chromatographic separation of at least one component from a mixture, comprising:
- a number of chromatographic columns or chromatographic column sections that contain an adsorbent, said columns or column sections being arranged in series and in a loop;
said loop comprising a number of fluid injection lines in each column or column section that are connected to at least one injection pump, and a number of fluid draw-off lines of each column or column section that are connected to at least one draw-off means, each line having at least one valve;
said loop defining at least three chromatographic zones, each chromatographic zone being determined by a fluid injection point and a fluid draw-off point;
said apparatus further comprising means for controlling and varying the length of each zone connected to said valves and for intermittently shifting, by at least a column or column section, the positions of the injection points and draw-off points;
said apparatus being a non-SMB apparatus.
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Accused Products
Abstract
A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable. The process is useful for the separation particularly of steroisomers for pharmaceuticals.
105 Citations
7 Claims
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1. A non-simulated-moving-bed (non SMB) apparatus for chromatographic separation of at least one component from a mixture, comprising:
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a number of chromatographic columns or chromatographic column sections that contain an adsorbent, said columns or column sections being arranged in series and in a loop;
said loop comprising a number of fluid injection lines in each column or column section that are connected to at least one injection pump, and a number of fluid draw-off lines of each column or column section that are connected to at least one draw-off means, each line having at least one valve;
said loop defining at least three chromatographic zones, each chromatographic zone being determined by a fluid injection point and a fluid draw-off point;
said apparatus further comprising means for controlling and varying the length of each zone connected to said valves and for intermittently shifting, by at least a column or column section, the positions of the injection points and draw-off points;
said apparatus being a non-SMB apparatus. - View Dependent Claims (2, 3, 4, 5)
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6. A non-simulated-moving-bed (non-SMB) apparatus for chromatographic separation of at least one component from a mixture, comprising:
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a number of chromatographic columns or chromatographic column sections that contain an adsorbent, said columns or column sections being arranged in series and in a loop;
said loop comprising at least one feedstock injection point, a raffinate draw-off point, an eluant injection point and an extract draw-off point;
said loop defining more than one chromatographic zone, each zone being determined by an injection point and a draw-off point;
wherein said apparatus further comprises means for shifting the injection points and draw off points after a given time period by the same number of columns or column sections; and
wherein said shifting of different injection points and draw off points is performed at different times, so that the lengths of each of said chromatographic zones is variable;
said apparatus being a non-SMB apparatus. - View Dependent Claims (7)
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Specification