Aqueous anti-apoptotic compositions

• US 6,413,556 B1
• Filed: 01/07/2000
• Issued: 07/02/2002
• Est. Priority Date: 01/08/1999
• Status: Expired due to Fees

• Current Assignee: Kenrico, Ltd.
• Original Assignee: Sky High, LLC
• Inventors: Bathurst, Ian C., Foehr, Matthew W.
• Primary Examiner(s): Tate, Christopher R.
• Assistant Examiner(s): Flood, Michele C.
• Application Number:
  US09/479,431
• Time in Patent Office: 907 Days
• Field of Search: 424/195.1, 424/210, 424/757, 424/725, 435/283, 435/1.1, 435/1.2
• US Class Current: 424/757
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/5488 Soybean protein
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae

Abstract

The present invention provides methods for extracting anti-apoptotic compositions from various protein isolates and/or lipid mixtures with aqueous solutions not containing organic solvents. The compositions extracted by the methods can be used for a variety of purposes, including for therapeutic, nutritional and medicinal purposes.

Claims

1. A method for extracting an anti-apoptotic composition from a protein isolate derived from a soy protein isolate, a soy lipid mixture or a combination thereof, comprising the steps of:

supplying said soy protein isolate, a soy lipid mixture or a combination thereof which has not been delipidated;

mixing said soy protein isolate, a soy lipid mixture or combination thereof in an aqueous solution not containing an organic solvent; and

separating the aqueous solution from insoluble material, wherein said anti-apoptotic composition is present in said aqueous solution.

2. The method of claim 1, wherein said protein isolate is derived from plants in the Leguminosae family.

3. The method of claim 1, wherein said combination of soy protein isolate and soy lipid mixture is in a ratio of 4:

1 (protein isolate;

lipid mixture).

4. The method of claim 1, further comprising the step of drying the aqueous solution to obtain a dried anti-apoptotic composition.

5. An anti-apoptotic composition produced by the method of claim 1.

6. The anti-apoptotic composition of claim 5, wherein said composition is combined with edible ingredients to produce a nutritional supplement or a medical food.

7. A method for the treatment or reduction of an adverse condition associated with apoptosis, comprising the step of:

administering a therapeutically effective amount of the anti-apoptotic composition, as claimed in claim 1 to a mammal in need of treatment or prevention of an adverse condition associated with apoptosis.

8. The method of claim 7, wherein said adverse condition is a gastrointestinal disorder.

9. The method of claim 8, wherein said gastrointestinal disorder is diarrhea.