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Silicon amphiphilic compounds and the use thereof

  • US 6,414,139 B1
  • Filed: 09/03/1996
  • Issued: 07/02/2002
  • Est. Priority Date: 09/03/1996
  • Status: Expired due to Fees
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58
Forward Citations
4
Assignments
First Claim
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1. A compound of the formula:

  • embedded imagewherein;

    each X1 is independently —

    O—

    , —

    S—

    , —

    SO—

    , —

    SO2—

    , —

    NR4—

    , —

    X3—

    C(═

    X4)—

    , —

    C(═

    X4)—

    X3—

    or —

    C(═

    X4)—

    ;

    X2 is —

    R5—

    X3—

    R6—

    , —

    R5—

    X3—

    C(═

    X4)—

    R6—

    , —

    R5—

    C(═

    X4)—

    X3—

    R6—

    , —

    R5—

    X3—

    C(═

    X4)—

    R6—

    C(═

    X4)—

    X5—

    R7—

    ,  

    —

    R5—

    X3—

    (YX3)P(═

    X4)—

    X3—

    R6—

    X5—

    C(═

    X4)—

    R6—

    C(═

    X4)—

    X3—

    or a saccharide diradical;

    each X3. is independently a direct bond, —

    O—

    , —

    NR4—

    or —

    S—

    ;

    each X4 is independently O or S;

    each X5 is independently —

    O—

    , —

    NR4—

    or —

    S—

    ;

    Y is hydrogen or a pharmaceutically acceptable counter ion;

    Z is a direct bond or a hydrophilic polymer;

    Q is a silicon residue;

    each R1 is independently optionally substituted alkyl of 1 to about 50 carbons;

    R2 is alkylene of 1 to about 30 carbons;

    each of R3 and R4 is independently hydrogen or alkyl of 1 to about 10 carbons; and

    each of R5, R6 and R7 is independently a direct bond or alkylene of 1 to about 30 carbons.

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