Implantable fluid delivery device for basal and bolus delivery of medicinal fluids

• US 6,416,495 B1
• Filed: 10/10/2000
• Issued: 07/09/2002
• Est. Priority Date: 10/10/2000
• Status: Expired due to Fees

• Current Assignee: Pescadero Beach Holdings Corporation
• Original Assignee: Science Incorporated
• Inventors: Thompson, Thomas N., Kriesel, Marshall S.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Hayes, Michael J
• Application Number:
  US09/686,650
• Time in Patent Office: 637 Days
• Field of Search: 604/19, 604/20, 604/93.01, 604/131-133, 604/153, 604/246, 604/82, 604/83, 604/85, 604/890.1, 604/891.1, 128/899, 128/DIG.12
• US Class Current: 604/132
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2209/045 for filling, e.g. for filling reservoirs
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: F03G 7/005 Electro-chemical actuators; Actuators having a material for absorbing or desorbing gas, e.g. a metal hydride; Actuators using the difference in osmotic pressure between fluids; Actuators with elements stretchable when contacted with liquid rich in ions, with UV light, with a salt solution
• CPC Class Codes: Y10S 977/777 Metallic powder or flake
• CPC Class Codes: Y10S 977/905 Specially adapted for travel through blood circulatory system

Abstract

An implantable fluid delivery apparatus for infusing medicinal fluids into a patient that includes a novel basal delivery system that includes a heat responsive polymer gel material which upon being heated by heater foil uniquely functions as an internal energy source for expelling basal doses of medicinal fluids from the device. The apparatus also includes a bolus delivery system that includes a magnetically responsive polymer gel which, upon being stimulated by an electro-magnet will delivery precise bolus doses of medicinal fluids to the patient.

Claims

1. An implantable device for implantation within a patient for infusing medicinal fluid into the patient comprising:

(a) a housing having an outlet;

(b) a first fluid reservoir containing a fluid disposed within said housing, said fluid reservoir having an inlet and an outlet in communication with said outlet of said housing;

(c) a first mass disposed within said housing proximate said first reservoir, said first mass comprising a semi-solid, which upon being stimulated, will act upon said fluid contained within said first reservoir to cause said fluid to flow outwardly of said outlet of said first reservoir;

(d) first stimulation means for stimulating said first mass, said first stimulation means being operably associated with said first mass;

(e) infusion means in communication with outlet of said housing for delivering fluid from said fluid reservoir to the patient; and

(f) bolus delivery means in communication with said infusion means for delivering a bolus dose of medicinal fluid to said patient.

2. The device as defined in claim 1 further including linear displacement measuring means disposed within said housing for determining the volume of fluid within said first fluid reservoir.

3. The device as defined in claim 1 in which said bolus delivery means comprises:

(a) a second reservoir disposed within said housing and containing a fluid, said second reservoir having an inlet and an outlet in communication with said outlet of said housing;

(b) a second mass disposed within said housing proximate said second reservoir, which upon being stimulated, will act upon said fluid contained within said second reservoir to cause said fluid to flow outwardly of said outlet of said second reservoir; and

(c) second stimulation means operably associated with said second mass for stimulating said second mass.

4. The device as defined in claim 3 in which said second mass is contained within an expandable structure disposed within said housing.

5. The device as defined in claim 3 in which said first mass comprises a thermo-responsive gel.

6. The device as defined in claim 3 in which said second mass comprises a magnetically stimulated gel.

7. The device as defined in claim 3 in which said second mass comprises an electro-responsive gel.

8. The device as defined in claim 3 further including infusion means connected to said housing and communicating with said first reservoir for delivering fluid from said first reservoir to the patient.

9. The device as defined in claim 3 in which said second reservoir is in communication with said first reservoir.

10. The device as defined in claim 3 further including linear displacement measurement means carried within said housing for measuring the volume of a fluid within said first fluid reservoir.

11. The device as defined in claim 3 further including fill means in communication with said first reservoir for filling said first reservoir.

12. The device as defined in claim 11 in which said fill means comprises a fill line and a remote fill septum in communication with said inlet of said first fluid reservoir, said septum being pierceable by a cannula inserted into said septum.

13. The device as defined in claim 11 further including sensor means connected to said housing for sensing physiological changes in the patient.

14. An implantable device for implantation within a patient for infusing medicinal fluid into the patient comprising:

(a) a housing having an outlet;

(b) a first fluid reservoir containing a fluid disposed within said housing, said first fluid reservoir having an inlet and an outlet in communication with said outlet of said housing;

(c) a first mass disposed within said housing proximate said first reservoir, said first mass comprising a semi-solid, which upon being stimulated, will act upon said fluid contained within said first reservoir to cause said fluid to flow outwardly of said outlet of said first reservoir;

(d) first stimulation means operably associated with said first mass for stimulating said first mass;

(e) a second reservoir containing fluid disposed within said housing, said second reservoir having an inlet and an outlet in communication with said outlet of said housing;

(f) a second mass disposed within said housing proximate said second reservoir, which upon being stimulated, will act upon said fluid contained within said second reservoir to cause said fluid to flow outwardly of said outlet of said second reservoir; and

(g) second stimulation means operably associated with said second mass for stimulating said second mass.

15. The device as defined in claim 14 in which said first mass is disposed within an expandable structure disposed within said housing.

16. The device as defined in claim 14 in which said first mass comprises a thermo-responsive gel.

17. The device as defined in claim 14 in which said first mass comprises a light stimulated gel.

18. The device as defined in claim 14 in which said second mass comprises a magnetically stimulated gel.

19. The device as defined in claim 14 in which said second mass comprises an electro-responsive polymer.

20. The device as defined in claim 14 further including linear displacement measuring means carried within said housing for determining the volume of fluid within said first fluid reservoir.

21. The device as defined in claim 14 further including infusion means connected to said housing for infusing medicinal fluid into the patient, said infusion means comprising a cannula connected to said outlet of said housing.

22. The device as defined in claim 14 in which said second reservoir is in communication with said first reservoir.

23. The device as defined in claim 14 further including sensor means connected to said housing for detecting physiochemical changes in the patient'"'"'s body.

24. The device as defined in claim 14 in which said second mass comprises a laminate gel construction.

25. The device as defined in claim 14 in which said second mass comprises a solid polymeric electrolyte disposed between two electrically conducting polymers.

26. The device as defined in claim 14 further including fill means in communication with said first reservoir for filling said first reservoir.

27. The device as defined in claim 26 in which said fill means comprises a fill line and a fill septum in communication with said inlet of said first fluid reservoir, said septum being pierceable by a cannula inserted into said septum.

28. An implantable device for implantation within a patient for infusing medicinal fluid into the patient comprising:

(a) a housing having an outlet;

(b) a first fluid reservoir containing a fluid disposed within said housing and containing a fluid, said fluid reservoir comprising an expandable structure having an inlet and an outlet in communication with said outlet of said housing;

(c) a first mass disposed within said housing proximate said first reservoir, said first mass comprising a polymer gel, which upon being stimulated, will act upon said fluid contained within said first reservoir to cause said fluid to flow outwardly of said outlet of said first reservoir;

(d) first stimulation means for stimulating said first mass, said first stimulation means being operably associated with said first mass;

(e) infusion means in communication with outlet of said housing for delivering fluid from said fluid reservoir to the patient;

(f) bolus delivery means in communication with said infusion means for delivering a bolus dose of medicinal fluid to said patient; and

(g) linear displacement measuring means disposed within said housing for determining the volume of fluid within said first fluid reservoir.

29. The device as defined in claim 28 in which said linear displacement measuring means comprises a magnet and an operably associated waveguide disposed within said housing.

30. The device as defined in claim 28 in which said linear displacement measuring means comprises magnetostrictive sensor.

31. The device as defined in claim 28 further including fill means in communication with said first reservoir for filling said reservoir.

32. The device as defined in claim 31 in which said fill means comprises a fill line and a fill septum in communication with said inlet of said first fluid reservoir, said septum being pierceable by a cannula inserted into said septum.

33. The device as defined in claim 32 further including sensor means connected to said housing for sensing physiological changes in the patient.