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Drug delivery catheters that attach to tissue and methods for their use

  • US 6,416,510 B1
  • Filed: 10/13/1999
  • Issued: 07/09/2002
  • Est. Priority Date: 03/13/1997
  • Status: Expired due to Term
First Claim
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1. The method of delivery of a therapeutic agent selected from the set of macromolecule, gene therapy preparation, microspheres, or micelles to a depth within the myocardium including the steps of:

  • providing a catheter adapted for insertion into the heart, said catheter having a proximal end and a distal end, said catheter having a fixating penetrating element secured to the distal end thereof, said catheter having a drug delivery lumen extending from the proximal end to the distal end of the catheter and a drug delivery port at the distal end of the catheter communicating from the drug delivery lumen to the exterior of the catheter;

    inserting the catheter into the heart, and manipulating the fixating penetrating element to engage the heart wall and releasably connect the catheter distal tip to the heart wall;

    manipulating the fixating penetrating element to cause it to penetrate the heart wall; and

    infusing the therapeutic agent to a depth within the heart wall.

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