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Increasing bone strength with selected bisphosphonates

  • US 6,416,737 B1
  • Filed: 11/19/1999
  • Issued: 07/09/2002
  • Est. Priority Date: 11/19/1998
  • Status: Expired due to Fees
First Claim
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1. A method of screening for a compound that increases bone strength, that includes the steps of:

  • i. a) contacting osteocytes with a test compound; and

    b) comparing the number of apoptotic osteocytes contacted with the test compound with the number of apoptotic osteocytes in a control wherein osteocytes are not contacted with the compound;

    ii. a) contacting osteoblasts with the test compound; and

    b) comparing the number of apoptotic osteoblasts contacted with the test compound with the number of apoptotic osteoblasts in a control wherein osteoblasts are not contacted with the test compound;

    iii. a) contacting osteoclasts with the test compound; and

    b) comparing the number of apoptotic osteoclasts contacted with the test compound with the number of apoptotic osteoclasts in a control wherein osteoclasts are not contacted with the test compound; and

    iv. selecting a test compound that inhibits the apoptosis of osteocytes and osteoblasts and does not substantially affect the apoptosis of osteoclasts.

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