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Physical separation of nucleic acids by antibodies to halogenated nucleotides

  • US 6,417,343 B1
  • Filed: 10/16/1997
  • Issued: 07/09/2002
  • Est. Priority Date: 10/17/1996
  • Status: Expired due to Fees
First Claim
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1. A method for labeling RNA by incorporating a 5-position halogenated pyrimidine into the RNA by the steps of:

  • (i) incubating the RNA with 5-position halogenated pyrimidine under conditions whereby the incorporation can occur, (ii) incubating the RNA having incorporated therein a portion of said 5-position halogenated pyrimidine, the incorporated form being a monophosphate pyrimidine, as formed in step (i) with anti-halogenated pyrimidine antibody which binds specifically to said halogenated pyrimidine providing for a means for labeling RNA (iii) separating the labeled RNA from non-labeled RNA.

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