Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system

• US 6,419,648 B1
• Filed: 04/21/2000
• Issued: 07/16/2002
• Est. Priority Date: 04/21/2000
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec-Txsonics Limited
• Inventors: Vitek, Shuki, Brenner, Naama
• Primary Examiner(s): Shaw, Shawna J.
• Application Number:
  US09/556,095
• Time in Patent Office: 816 Days
• Field of Search: 600/437, 600/439, 601/2, 601/3, 601/4, 604/22, 606/27
• US Class Current: 601/3
• CPC Class Codes: A61B 8/4494 characterised by the arrangement of the transducer elements devices for short-range imaging using particular transducer elements arrangements under G01S15/8909; arrangements of transducers in generation of mechanical vibrations of infrasonic, sonic or ultrasonic frequency B06B1/0607
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0073 using multiple frequencies
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: B06B 1/0284 with consecutive, i.e. sequential generation, e.g. with frequency sweep
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

System and methods for performing a therapeutic procedure using focused ultrasound include providing a piezoelectric transducer including a plurality of transducer elements, such as a concave concentric ring array or a liner array of transducer elements. Drive circuitry is coupled to the transducer for providing drive signals to the transducer elements at one of a plurality of discrete RF frequencies. A controller is coupled to the drive circuitry for periodically changing a frequency of the drive signals to one of the plurality of discrete frequencies, while controlling a phase component of the drive signals to maintain the focus of the transducer at a primary focal zone during a single sonication.

Claims

1. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound within a primary focal zone, comprising:

an array of transducer elements;

drive circuitry coupled to the transducer elements, the drive circuitry configured to provide respective drive signals to the transducer elements of at least first, second, and third discrete frequencies; and

a controller coupled to the drive circuitry, the controller configured for periodically changing the frequency of the respective drive signals provided by the drive circuitry between at least the first, second, and third frequencies while substantially maintaining focus at the primary focal zone during a single, substantially continuous, sonication, the controller changing the frequency less than once every 50 milliseconds.

2. The system of claim 1, wherein the controller is further configured for controlling a phase component of the respective drive signals to focus the transducer elements substantially at the primary focal zone at the firsts second and third frequencies.

3. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

driving a plurality of transducer elements with a set of respective drive signals at a first discrete frequency, while focusing ultrasonic energy produced by the transducer elements at a primary focal zone within the target tissue region and creating a secondary focal zone at a location outside the primary focal zone; and

changing the frequency of the respective drive signals to a second discrete frequency, while substantially maintaining the focus at the primary focal zone and moving the secondary focal zone to another location outside the primary focal zone;

wherein the frequency is changed less than once every 50 ms.

4. The method of claim 3, wherein each drive signal has a respective phase component, and wherein the respective phase components of the drive signals are controlled when the frequency of the respective drive signals is changed, in order to substantially maintain the focus at the primary focal zone.

5. The method of claim 3, wherein the transducer elements comprise a concentric ring array divided circumferentially into a plurality of curved elements, and wherein a phase component of the respective drive signals driving each of the curved elements is controlled to provide a desired size and shape of the primary focal zone.

6. The method of claim 3, wherein the step of changing the frequency comprises alternating the frequency of the respective drive signals between a fixed set of frequencies comprising the first and second frequencies during a single sonication.

7. The method of claim 6, wherein the fixed set of frequencies includes one or more additional frequencies in addition to the first and second frequencies, and wherein the frequency of the respective drive signals is alternated in a predetermined sequence.

8. The method of claim 6, wherein the frequency of the respective drive signals is alternated between the fixed set of frequencies no more than once every 0.2 second.

9. The method of claim 8, wherein the frequency of the respective drive signals is alternated between the fixed set of frequencies at most once every second.

10. The method of claim 8, wherein the frequency of the respective drive signals is alternated between the fixed set of frequencies every 0.2-0.5 second.

11. The method of claim 6, wherein the sonication has a duration of about ten (10) seconds or more.

12. The method of claim 6, wherein the sonication having a duration of between about 5-20 seconds.

13. The method of claim 6, wherein the frequency of the respective drive signals is alternated between the fixed set of frequencies no more than 10-100 times during a single sonication.

14. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

driving a plurality of transducer elements with a first set of respective drive signals at a first frequency for longer than 50 ms, while focusing ultrasonic energy produced by the transducer elements substantially at a primary focal zone within the target tissue region and creating a secondary focal zone outside the primary focal zone; and

driving the plurality of transducer elements with a second set of respective drive signals at a second frequency for longer than 50 ms, while maintaining the focus of the ultrasonic energy produced by the transducer elements substantially at the primary focal zone and moving the secondary focal zone to another location outside the primary focal zone.

15. The method of claim 14, wherein the ultrasonic energy of the transducer elements is focused at the primary focal zone by controlling a phase component of the respective drive signals.

16. The method of claim 14, wherein the transducer elements comprise a concentric ring array divided circumferentially into a plurality of curved elements, and wherein a phase component of the respective drive signals driving each of the curved elements is controlled to provide a desired size and shape of the primary focal zone.

17. The method of claim 14, comprising the additional step of driving the plurality of transducer elements with a third set of respective drive signals at a third frequency, while maintaining the focus of the ultrasonic energy produced by the transducer elements substantially at the primary focal zone.

18. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound within a primary focal zone, comprising:

an array of transducer elements;

drive circuitry coupled to the transducer elements, the drive circuitry configured to provide respective drive signals to the transducer elements of at least first and second discrete frequencies; and

a controller coupled to the drive circuitry for periodically changing the frequency of the respective drive signals provided by the drive circuitry between at least the first and second frequencies while substantially maintaining focus at the primary focal zone, the controller maintaining the respective drive signals at the first frequency for at least 0.2 second before changing the respective drive signals to the second frequency.

19. The system of claim 18, wherein the controller is configured for changing the frequency of the respective drive signals at most once every second during a single sonication.

20. The system of claim 19, wherein the controller is configured for changing the frequency of the respective drive signals every 0.2-0.5 second signals during a single sonication.

21. The system of claim 18, wherein the controller is configured for periodically changing the frequency of the respective drive signals between a plurality of discrete frequencies in a predetermined sequence during a single sonication having a duration of about ten (10) seconds or more.

22. The system of claim 18, wherein the controller is configured for periodically changing the frequency of the respective drive signals between a plurality of discrete frequencies in a predetermined sequence during a single, substantially continuous sonication having a duration of between about 5-20 seconds.

23. The system of claim 18, wherein the controller is further configured for controlling a phase component of the respective drive signals to focus the transducer elements substantially at a primary focal zone at the first and second frequencies, while changing a location of a secondary focal zone outside the primary focal zone.

24. The system of claim 18, wherein the controller is configured for maintaining the respective drive signals at the second frequency for at least 0.2 second before changing the frequency of the respective drive signals.

25. The system of claim 18, wherein the controller is configured for changing the frequency of the respective drive signals no more than 10-100 times during a single sonication.