Microarray hybridization chamber
First Claim
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1. An apparatus for mixing a fluid, the apparatus comprising:
- a first substrate comprising a first inner surface functionalized with a microarray of reactive moieties;
a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
at least one bubble disposed within said chamber; and
means for moving the chamber so that the bubble moves relative to the fluid to effect mixing of the fluid.
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Abstract
A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids, undergoing a reaction. The apparatus comprises a means for creating a bubble within the film of fluid, and moving the bubble in the fluid, thereby mixing the fluid.
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Citations
30 Claims
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1. An apparatus for mixing a fluid, the apparatus comprising:
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a first substrate comprising a first inner surface functionalized with a microarray of reactive moieties;
a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
at least one bubble disposed within said chamber; and
means for moving the chamber so that the bubble moves relative to the fluid to effect mixing of the fluid. - View Dependent Claims (3, 5, 7, 9, 10, 11, 12, 13, 14, 16, 18, 20, 22, 23, 25, 27, 29, 30)
providing an apparatus according to claim 1;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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25. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 3;
introducing a fluid into the closed chamber, introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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27. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 5;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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29. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 9;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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30. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 22;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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2. An apparatus for mixing a fluid, the apparatus comprising:
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a first substrate comprising a first inner surface functionalized with a microarray of reactive moieties;
a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
at least one bubble disposed within said chamber, wherein said bubble is a magnetic particle; and
means for moving the bubble relative to the fluid to effect mixing of the fluid. - View Dependent Claims (4, 6, 8, 15, 17, 19, 21, 24, 26, 28)
providing an apparatus according to claim 2;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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26. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 4;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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28. A method for mixing a fluid, comprising:
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providing an apparatus according to claim 6;
introducing a fluid into the closed chamber;
introducing a bubble within the fluid; and
moving the bubble in the fluid to effect mixing of the fluid.
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Specification