Combinatorial sythesis of organometallic materials
First Claim
1. A method of making an array of organometallic compounds, said method comprisingforming at least ten different organometallic compounds at discrete regions of a single substrate, the at least ten different organometallic compounds being formed by a method that includes delivering a first component of a first organometallic compound, a second organometallic compound, a third organometallic compound, a fourth organometallic compound, a fifth organometallic compound, a sixth organometallic compound, a seventh organometallic compound, an eighth organometallic compound, a ninth organometallic compound and a tenth organometallic compound to first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, and delivering a second component of said first organometallic compound, second organometallic compound, third organometallic compound, fourth organometallic compound, fifth organometallic compound, sixth organometallic compound, seventh organometallic compound, eighth organometallic compound, ninth organometallic compound and tenth organometallic compound to said first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions being isolated such that the organometallic compounds or components thereof cannot, after being formed on or delivered to the substrate, interdiffuse between adjacent regions.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
77 Citations
81 Claims
-
1. A method of making an array of organometallic compounds, said method comprising
forming at least ten different organometallic compounds at discrete regions of a single substrate, the at least ten different organometallic compounds being formed by a method that includes delivering a first component of a first organometallic compound, a second organometallic compound, a third organometallic compound, a fourth organometallic compound, a fifth organometallic compound, a sixth organometallic compound, a seventh organometallic compound, an eighth organometallic compound, a ninth organometallic compound and a tenth organometallic compound to first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, and delivering a second component of said first organometallic compound, second organometallic compound, third organometallic compound, fourth organometallic compound, fifth organometallic compound, sixth organometallic compound, seventh organometallic compound, eighth organometallic compound, ninth organometallic compound and tenth organometallic compound to said first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions being isolated such that the organometallic compounds or components thereof cannot, after being formed on or delivered to the substrate, interdiffuse between adjacent regions.
-
24. A method of making an array of organometallic compounds, said method comprising:
-
forming at least ten different organometallic compounds on at least ten substrates, respectively, each of the at least ten substrates comprising an identifier tag, the at least ten different organometallic compounds being formed by a method that includes delivering a first component of a first organometallic compound to a first substrate, delivering a first component of a second organometallic compound to a second substrate, delivering a first component of a third organometallic compound to a third substrate, delivering a first component of a fourth organometallic compound to a fourth substrate, delivering a first component of a fifth organometallic compound to a fifth substrate, delivering a first component of a sixth organometallic compound to a sixth substrate, delivering a first component of a seventh organometallic compound to a seventh substrate, delivering a first component of an eighth organometallic compound to an eighth substrate, delivering a first component of a ninth organometallic compound to a ninth substrate, delivering a first component of a tenth organometallic compound to a tenth substrate, delivering a second component of the first organometallic compound to said first substrate, delivering a second component of the second organometallic compound to said second substrate, delivering a second component of the third organometallic compound to said third substrate, delivering a second component of the fourth organometallic compound to said fourth substrate, delivering a second component of the fifth organometallic compound to said fifth substrate, delivering a second component of the sixth organometallic compound to said sixth substrate, delivering a second component of the seventh organometallic compound to said seventh substrate, delivering a second component of the eighth organometallic compound to said eighth substrate, delivering a second component of the ninth organometallic compound to said ninth substrate, delivering a second component of the tenth organometallic compound to said tenth substrate, allowing said first and second components of the first organometallic compound to react to form the first organometallic compound on the first substrate, allowing said first and second components of the second organometallic compound to react to form the second organometallic compound on the second substrate, allowing said first and second components of the third organometallic compound to react to form the third organometallic compound on the third substrate, allowing said first and second components of the fourth organometallic compound to react to form the fourth organometallic compound on the fourth substrate, allowing said first and second components of the fifth organometallic compound to react to form the fifth organometallic compound on the fifth substrate, allowing said first and second components of the sixth organometallic compound to react to form the sixth organometallic compound on the sixth substrate, allowing said first and second components of the seventh organometallic compound to react to form the seventh organometallic compound on the seventh substrate, allowing said first and second components of the eighth organometallic compound to react to form the eighth organometallic compound on the eighth substrate, allowing said first and second components of the ninth organometallic compound to react to form the ninth organometallic compound on the ninth substrate, and allowing said first and second components of the tenth organometallic compound to react to form the tenth organometallic compound on the tenth substrate. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
(i) establishing a frame of reference common to a dispenser and one of the at least ten substrates, (ii) moving the dispenser of said component such that said dispenser is positioned approximately above said substrate;
(iii) delivering said component to said substrate; and
(iv) repeating steps (ii) and (iii) for each remaining component.
-
-
34. The method as recited in claim 24 wherein said array comprises at least 100 different organometallic compounds on at least 100 substrates, respectively.
-
35. The method as recited in claim 24 wherein said array comprises at least 1000 different organometallic compounds on at least 1000 substrates, respectively.
-
36. The method as recited in claim 24 further comprising the step of screening said array of organometallic compounds for a useful property.
-
37. The method as recited in claim 36 wherein said useful property is a member selected from the group consisting of an electrical property, a thermal property, a mechanical property, a morphological property, an optical property, a magnetic property and a chemical property.
-
38. The method as recited in claim 37 wherein said useful property is a thermal property and said useful property is measured using infrared.
-
39. The method as recited in claim 37 wherein said useful property is a chemical property and said useful property is measured using infrared.
-
40. The method as recited in claim 36 wherein said useful property is the property of catalysis.
-
41. The method as recited in claim 36 wherein said useful property is screened for using spectroscopic techniques.
-
42. The method as recited in claim 36 wherein said array of organometallic compounds is screened in parallel.
-
43. The method as recited in claim 36 wherein said array of organometallic compounds is screened sequentially.
-
44. A method of making an array of organometallic compounds, said method comprising
forming at least ten different organometallic compounds on at least ten solid supports, respectively, the at least ten different organometallic compounds being formed by a method that includes (a) apportioning solid supports among at least ten reaction vessels, (b) exposing said apportioned solid supports in each reaction vessel to a first component of the organometallic compounds, (c) pooling said exposed solid supports, (d) optionally reapportioning the pooled solid supports among said at least ten reaction vessels, (e) exposing said pooled or said optionally reapportioned solid supports to a second component of the organometallic compounds, and (f) allowing said first and second components to react, either the first components being different from each other or the second components being different from each other, such that at least ten different organometallic compounds are formed on at least ten solid supports, respectively.
-
64. A method of making an array of organometallic compounds, said method comprising
forming at least ten different organometallic compounds at discrete regions of a single substrate, the at least ten different organometallic compounds being formed by a method that includes delivering a first component of a first organometallic compound, a second organometallic compound, a third organometallic compound, a third organometallic compound, a fourth organometallic compound, a fifth organometallic compound, a sixth organometallic compound, a seventh organometallic compound, an eighth organometallic compound, a ninth organometallic compound and a tenth organometallic compound to first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, and delivering a second component of said first organometallic compound, second organometallic compound, third organometallic compound, fourth organometallic compound, fifth organometallic compound, sixth organometallic compound, seventh organometallic compound, eighth organometallic compound, ninth organometallic compound and tenth organometallic compound to said first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions of said substrate, respectively, the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions being defined by vessels.
-
66. A method of making an array of organometallic compounds, said method comprising
forming at least ten different organometallic compounds on at least ten solid supports, respectively, the supports being provided at discrete regions of a substrate, the at least ten different organometallic compounds being formed by a method that includes delivering a first component and a second component of a first organometallic compound to a first support at a first region of the substrate, and allowing the first and second components of the first organometallic compound to react to form the first organometallic compound on the first support, delivering a first component and a second component of a second organometallic compound to a second support at a second region of the substrate, and allowing the first and second components of the second organometallic compound to react to form the second organometallic compound on the second support, delivering a first component and a second component of a third organometallic compound to a third support at a third region of the substrate, and allowing the first and second components of the third organometallic compound to react to form the third organometallic compound on the third support, delivering a first component and a second component of a fourth organometallic compound to a fourth support at a fourth region of the substrate, and allowing the first and second components of the fourth organometallic compound to react to form the fourth organometallic compound on the fourth support, delivering a first component and a second component of a fifth organometallic compound to a fifth support at a fifth region of the substrate, and allowing the first and second components of the fifth organometallic compound to react to form the fifth organometallic compound on the fifth support, delivering a first component and a second component of a sixth organometallic compound to a sixth support at a sixth region of the substrate, and allowing the first and second components of the sixth organometallic compound to react to form the sixth organometallic compound on the sixth support, delivering a first component and a second component of a seventh organometallic compound to a seventh support at a seventh region of the substrate, and allowing the first and second components of the seventh organometallic compound to react to form the seventh organometallic compound on the seventh support, delivering a first component and a second component of an eighth organometallic compound to a eighth support at a eighth region of the substrate, and allowing the first and second components of the eighth organometallic compound to react to form the eighth organometallic compound on the eighth support, delivering a first component and a second component of a ninth organometallic compound to a ninth support at a ninth region of the substrate, and allowing the first and second components of the ninth organometallic compound to react to form the ninth organometallic compound on the ninth support, and delivering a first component and a second component of a tenth organometallic compound to a tenth support at a tenth region of the substrate, and allowing the first and second components of the tenth organometallic compound to react to form the tenth organometallic compound on the tenth support, the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions being isolated such that the organometallic compounds or components thereof cannot, after being formed on or delivered to the supports, interdiffuse between adjacent regions.
-
76. A method of making an array of organometallic compounds, said method comprising
forming at least ten different organometallic compounds on at least ten solid supports, respectively, the supports being provided at discrete regions of a substrate, the at least ten different organometallic compounds being formed by a method that includes delivering a first component and a second component of a first organometallic compound to a first support at a first region of the substrate, and allowing the first and second components of the first organometallic compound to react to form the first organometallic compound on the first support, delivering a first component and a second component of a second organometallic compound to a second support at a second region of the substrate, and allowing the first and second components of the second organometallic compound to react to form the second organometallic compound on the second support, delivering a first component and a second component of a third organometallic compound to a third support at a third region of the substrate, and allowing the first and second components of the third organometallic compound to react to form the third organometallic compound on the third support, delivering a first component and a second component of a fourth organometallic compound to a fourth support at a fourth region of the substrate, and allowing the first and second components of the fourth organometallic compound to react to form the fourth organometallic compound on the fourth support, delivering a first component and a second component of a fifth organometallic compound to a fifth support at a fifth region of the substrate, and allowing the first and second components of the fifth organometallic compound to react to form the fifth organometallic compound on the fifth support, delivering a first component and a second component of a sixth organometallic compound to a sixth support at a sixth region of the substrate, and allowing the first and second components of the sixth organometallic compound to react to form the sixth organometallic compound on the sixth support, delivering a first component and a second component of a seventh organometallic compound to a seventh support at a seventh region of the substrate, and allowing the first and second components of the seventh organometallic compound to react to form the seventh organometallic compound on the seventh support, delivering a first component and a second component of an eighth organometallic compound to a eighth support at a eighth region of the substrate, and allowing the first and second components of the eighth organometallic compound to react to form the eighth organometallic compound on the eighth support, delivering a first component and a second component of a ninth organometallic compound to a ninth support at a ninth region of the substrate, and allowing the first and second components of the ninth organometallic compound to react to form the ninth organometallic compound on the ninth support, and delivering a first component and a second component of a tenth organometallic compound to a tenth support at a tenth region of the substrate, and allowing the first and second components of the tenth organometallic compound to react to form the tenth organometallic compound on the tenth support, the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth and tenth regions being defined by vessels.
Specification