Small molecule modulators of G protein-coupled receptor six

• US 6,420,563 B1
• Filed: 02/25/2000
• Issued: 07/16/2002
• Est. Priority Date: 07/31/1998
• Status: Expired due to Term

• Current Assignee: Arena Pharmaceuticals Incorporated (Pfizer Inc.)
• Original Assignee: Arena Pharmaceuticals Incorporated (Pfizer Inc.)
• Inventors: Strah-Pleynet, Sonja, Chalmers, Derek T., Menzaghi, Frederique, Beeley, Nigel R. A., Behan, Dominic P.
• Primary Examiner(s): Higel, Floyd D.
• Application Number:
  US09/513,838
• Time in Patent Office: 872 Days
• Field of Search: 548/323.1, 548/303.1, 548/311.4, 548/315.4, 548/314.4, 548/240, 514/397, 514/398, 514/338, 514/341, 546/273.1, 546/274.4
• US Class Current: 546/273.1
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 233/42 Sulfur atoms
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 513/04 Ortho-condensed systems
• CPC Class Codes: G01N 2333/726 G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
• CPC Class Codes: G01N 2500/00 Screening for compounds of potential therapeutic value
• CPC Class Codes: G01N 33/68 involving proteins, peptides or amino acids involving lipoproteins G01N33/92

Abstract

Disclosed herein are small molecule modulators of the G protein coupled receptor six, methods of making such compounds, and methods of using such compounds.

Claims

1. A small molecule, GPR6 inverse agonist selected from the group consisting of the following structures: