Method for determining the baroreflex latent period and baroreflex sensitivity

• US 6,421,557 B1
• Filed: 06/29/2000
• Issued: 07/16/2002
• Est. Priority Date: 06/29/1999
• Status: Expired due to Term

• Current Assignee: Biotronik Mess-Und Therapiegeraete GmbH & Company Ingenieurbuero Berlin (Biotronik SE & Company KG)
• Original Assignee: Biotronik Mess-Und Therapiegeraete GmbH & Company Ingenieurbuero Berlin (Biotronik SE & Company KG)
• Inventors: Meyer, Wolfgang
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US09/605,832
• Time in Patent Office: 747 Days
• Field of Search: 600/515, 600/516, 600/518
• US Class Current: 600/516
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle

Abstract

A method for determining the baroreflex provides a non-invasive measurement of cardiac-interval periods, and a mathematical analysis of these measurement values on the basis of non-linear dynamic methods.

Claims

1. A method for determining A baroreflex latent period, particularly A corresponding baroreflex sensitivity, comprising

a non-invasive measurement of cardiac-interval periods, and

a mathematical analysis of measurement values of the cardiac-interval periods on the basis of non-linear dynamic methods.

2. The method according to claim 1, wherein the non-linear dynamic analysis method comprises following steps:

an interpolation of the interval measurement values for determining a continuous measurement-value course from the discrete interval periods;

a graphing of the interpolated signal values in a three-dimensional phase space with abscissas y(t), y(t−

τ

) and d(y)/d(t) with different baroreflex latent periods being assumed for a parameter τ

;

a projection of the three-dimensional graph into a two-dimensional space through a determination of all values on a sectional plane perpendicular to one of the axes, with y(t) preferably being constant; and

a determination of an assumed baroreflex latent period for which a highest order can be established in the two-dimensional projection as being relevant.

3. The method according to claim 1, wherein the P-P, P-R and/or R-R cardiac intervals are measured non-invasively.