Cartridge washing system and methods

• US 6,422,249 B1
• Filed: 08/10/2000
• Issued: 07/23/2002
• Est. Priority Date: 08/10/2000
• Status: Expired due to Term

• Current Assignee: Affymetrix, Inc. (Thermo Fisher Scientific Incorporated)
• Original Assignee: Affymetrix, Inc. (Thermo Fisher Scientific Incorporated)
• Inventors: Certa, Ulrich, Tschirky, Hansjörg
• Primary Examiner(s): COE, PHILIP R
• Application Number:
  US09/636,517
• Time in Patent Office: 712 Days
• Field of Search: 134/166.R, 134/167.R, 134/168.R, 134/169.R, 134/62
• US Class Current: 134/168.00R
• CPC Class Codes: B01L 13/00 Cleaning or rinsing apparatus
• CPC Class Codes: B01L 13/02 for receptacle or instruments
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: G01N 2035/00158 Elements containing microarrays, i.e. "biochip"

Abstract

A washing system comprises a support for holding several cartridges. Each cartridge has a chamber with an inlet and an outlet. Wash blocks are movably coupled to the support, each having two needles for penetrating the inlet and the outlet of a respective cartridge when the wash blocks are moved towards the support. Tubing is coupled to the needles for flowing liquid through the chamber of the cartridge.

Claims

1. A washing system comprising:

a support for holding at least one cartridge including a chamber having an inlet and an outlet; and

at least one wash block movably coupled to the support and having an inlet needle and an outlet needle;

wherein the inlet needle penetrates the inlet of the chamber and the outlet needle penetrates the outlet of the chamber when the cartridge is held by the support and the wash block is moved towards the support.

2. A system as in claim 1, further comprising tubing coupled to the inlet needle.

3. A system as in claim 2, further comprising a supply of liquid supplying the tubing coupled to the inlet needle.

4. A system as in claim 3, further comprising a manifold disposed between the supply of liquid and the tubing coupled to the inlet needle.

5. A system as in claim 3, further comprising a pump circulating liquid from the supply of liquid to the inlet needle.

6. A system as in claim 1, further comprising tubing coupled to the outlet needle.

7. A system as in claim 1, wherein the wash block is resiliently urged against the support with a spring.

8. A system as in claim 1, further comprising a handling rod connected to the wash block.

9. A system as in claim 8, wherein the handling rod passes through the support.

10. A system as in claim 1, wherein the wash block has a protuberance for positioning the cartridge held by the support when the wash block is moved towards the support.

11. A system as in claim 1, wherein the support comprises a wall having a slot for receiving the cartridge.

12. A system as in claim 1, further comprising a member coupled to the support and having a channel, the inlet needle and the outlet needle penetrating in said channel when the wash block is moved towards the support free of a cartridge.

13. A system as in claim 1, wherein the support is asymmetrical to hold the cartridge in only one orientation.

14. A system as in claim 1, wherein the wash block is slidably coupled to the support.

15. A system as in claim 1, wherein the wash block is slidably mounted on at least one guiding rod of the support.

16. A system as in claim 15, further comprising at least a second wash block slidably mounted on the guiding rod, wherein the support is adapted to hold at least a second cartridge, the needles of the second wash block penetrating the inlet and the outlet of the second cartridge when the second cartridge is held by the support and the second wash block is moved towards the support.

17. A system as in claim 16, further comprising a spring arranged around the guiding rod between the first wash block and the second wash block, wherein the spring urges the first wash block and the second wash block towards the support.