Method and apparatus for enhanced plasmapheresis
First Claim
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1. A blood filtration apparatus comprising:
- a chamber having a hollow interior enclosed by a first plate, a second plates and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
means for directing blood into the chamber gap;
a non-rotational drive structure;
said second plate comprising filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
a collecting means;
means for directing the plasma constituent passing through said filter membrane means to said collecting means; and
means for directing from the chamber gap a remaining constituent of the blood out of the chamber.
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Abstract
An apparatus and methods for enhanced plasmapheresis comprising a filter membrane under an orbital motion or movement that has optimal local shear forces and maximum plasma flow output. The separation apparatus comprises a first plate, a second plate and a hollow interior therebetween, wherein the second plate is detachably coupled to a non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate for enhanced blood separation.
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Citations
20 Claims
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1. A blood filtration apparatus comprising:
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a chamber having a hollow interior enclosed by a first plate, a second plates and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
means for directing blood into the chamber gap;
a non-rotational drive structure;
said second plate comprising filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
a collecting means;
means for directing the plasma constituent passing through said filter membrane means to said collecting means; and
means for directing from the chamber gap a remaining constituent of the blood out of the chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A blood filtration method for use in separating filtrate from blood supply comprising the steps of:
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(a) feeding blood supply into a chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the first plate and the second plate, wherein the first plate is essentially parallel to the second plate so as to form a chamber gap for the hollow interior;
said second plate comprising filter membrane means for separating filtrate constituent from the blood, wherein the second plate is detachably coupled to a non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
(b) initiating orbital motion of the second plate by the non-rotational drive structure to effect enhanced separation of filtrate from blood supply;
(c) collecting the filtrate constituent passing through said filter membrane means; and
(d) discharging a remaining constituent of the blood from the chamber gap out of the chamber. - View Dependent Claims (19)
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20. A filtration system comprising:
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fluid supply means for supplying a fluid containing filtrate and particulate constituent;
a filtration chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the fist plate and the second plate, wherein the first plate is essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
means for directing the fluid supply into the hollow interior;
a non-rotational drive structure;
said second plate comprising filter membrane means for separating filtrate from the particulate constituent, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
a collecting means;
filtrate collecting means for directing the filtrate passing through said filter membrane means to said collecting means; and
particulate constituent collecting means for directing from the chamber gap a remaining constituent of the fluid supply out of the chamber.
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Specification