Method and apparatus for enhanced plasmapheresis

• US 6,423,023 B1
• Filed: 02/02/2000
• Issued: 07/23/2002
• Est. Priority Date: 02/02/2000
• Status: Expired due to Fees

• Current Assignee: Xepmed Incorporated
• Original Assignee: Daniel H. Duff, Hosheng Tu, Yu-An Chang
• Inventors: Duff, Daniel H., Chang, Yu-An, Tu, Hosheng
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Deak, Leslie R.
• Application Number:
  US09/496,613
• Time in Patent Office: 902 Days
• Field of Search: 210/637, 210/651, 210/247, 210/780-782, 210/209, 210/297, 210/385, 210/359, 210/107, 210/109, 210/321.87, 210/645, 210/767, 210/490, 210/483, 210/494, 210/360.1, 210/787, 604/6.04, 604/6.09
• US Class Current: 604/6.04
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 1/262 rotating
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: B01D 63/16 Rotary, reciprocated or vibrated modules

Abstract

An apparatus and methods for enhanced plasmapheresis comprising a filter membrane under an orbital motion or movement that has optimal local shear forces and maximum plasma flow output. The separation apparatus comprises a first plate, a second plate and a hollow interior therebetween, wherein the second plate is detachably coupled to a non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate for enhanced blood separation.

Claims

1. A blood filtration apparatus comprising:

a chamber having a hollow interior enclosed by a first plate, a second plates and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;

means for directing blood into the chamber gap;

a non-rotational drive structure;

said second plate comprising filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;

a collecting means;

means for directing the plasma constituent passing through said filter membrane means to said collecting means; and

means for directing from the chamber gap a remaining constituent of the blood out of the chamber.

2. The blood filtration apparatus as in claim 1, wherein the first plate is at an acute angle to the second plate and wherein the acute angle is in the range of 1 degree to 40 degrees.

3. The blood filtration apparatus as in claim 1, wherein the flexible seal element is selected from the group consisting of silicone, polyurethane, latex, Nylon, polyvinyl chloride, polyimide, polycarbonate, polyacrylate, polymethacrylate, polystyrene, polyethylene, polypropylene, mixture thereof, and copolymer thereof.

4. The blood filtration apparatus as in claim 1, wherein the chamber gap is between 0.001 to 0.1 inch.

5. The blood filtration apparatus as in claim 1, wherein the orbital motion is selected from the group consisting of clockwise movement, counter-clockwise movement and combination thereof.

6. The blood filtration apparatus as in claim 1, wherein the filter membrane means has pores of a size on the order of 0.2 to 1.0 μ

m.

7. The blood filtration apparatus as in claim 1 further comprising an off-center orbital motion, wherein the off-center orbital motion is within a range of 0.001 to 1.0 inch.

8. The blood filtration apparatus as in claim 1, wherein the orbital motion is at a frequency within a range of 500 to 50,000 cycles per minute.

9. The blood filtration apparatus as in claim 1, wherein the orbital motion is selected from the group consisting of circular shape movement, oval shape movement, peanut shape movement, pear shape movement, and irregular shape movement.

10. The blood filtration apparatus as in claim 1, wherein pressure within the means for directing blood into the chamber gap is higher than pressure within the means for directing the plasma constituent passing through said filter membrane means to said collecting means.

11. The blood filtration apparatus as in claim 1, wherein the means for directing blood into the chamber gap is located either at about a center of the first plate or at about a periphery of the first plate.

12. The blood filtration apparatus as in claim 1, wherein the means for directing the plasma constituent to said collecting means is located either at about a periphery of the second plate or at about a center of the second plate.

13. The blood filtration apparatus as in claim 12, wherein an interior surface of the second plate is ribbed and adapted for allowing the plasma constituent to pass through the filter membrane means to the collecting means.

14. The blood filtration apparatus as in claim 1, wherein the filter membrane means for separating the plasma constituent from the blood is selected from the group consisting of nylon membrane, polycarbonate membrane, polysulfone membrane, oval pore membrane, micro-fabricated membrane, tract-edged membrane and combination thereof.

15. The blood filtration apparatus as in claim 1, wherein the filter membrane means is partially attached to the second plate at a periphery of the second plate.

16. The blood filtration apparatus as in claim 1 further comprising a rotatable means, wherein the non-rotational drive structure is coupled to said rotatable means for generating orbital motion to the second plate.

17. The blood filtration apparatus as in claim 16, wherein the rotatable means is selected from the group consisting of rotatable magnetic motor and rotatable mechanical motor.

18. A blood filtration method for use in separating filtrate from blood supply comprising the steps of:

(a) feeding blood supply into a chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the first plate and the second plate, wherein the first plate is essentially parallel to the second plate so as to form a chamber gap for the hollow interior;

said second plate comprising filter membrane means for separating filtrate constituent from the blood, wherein the second plate is detachably coupled to a non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;

(b) initiating orbital motion of the second plate by the non-rotational drive structure to effect enhanced separation of filtrate from blood supply;

(c) collecting the filtrate constituent passing through said filter membrane means; and

(d) discharging a remaining constituent of the blood from the chamber gap out of the chamber.

19. The blood filtration method as in claim 18, wherein the blood supply comprises at least one component selected from the group consisting of red blood cell, white blood cell, and platelet.

20. A filtration system comprising:

fluid supply means for supplying a fluid containing filtrate and particulate constituent;

a filtration chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the fist plate and the second plate, wherein the first plate is essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;

means for directing the fluid supply into the hollow interior;

a non-rotational drive structure;

said second plate comprising filter membrane means for separating filtrate from the particulate constituent, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;

a collecting means;

filtrate collecting means for directing the filtrate passing through said filter membrane means to said collecting means; and

particulate constituent collecting means for directing from the chamber gap a remaining constituent of the fluid supply out of the chamber.