Variegated Kunitz domain peptide library and uses thereof
First Claim
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1. A library of Kunitz domain polypeptides, said polypeptides comprising expression products of polynucleotides encompassed by the sequence:
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Abstract
This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.
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Citations
4 Claims
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1. A library of Kunitz domain polypeptides, said polypeptides comprising expression products of polynucleotides encompassed by the sequence:
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2. A library of Kunitz domain polypeptides, said polypeptides comprising expression products of polynucleotides encompassed by the sequence:
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3. A library of Kunitz domain polypeptides, said polypeptides comprising expression products encoded by the sequence:
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4. A library of Kunitz domain polypeptides, said polypeptides comprising expression products encoded by the sequence:
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Current AssigneeDyax Corporation (Shire plc)
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Original AssigneeDyax Corporation (Shire plc)
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InventorsMarkland, William, Ladner, Robert Charles
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Primary Examiner(s)Carlson, Karen Cochrane
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Assistant Examiner(s)Robinson, Hope A.
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Application NumberUS09/638,770Time in Patent Office707 DaysField of Search424/9.2, 435/7.2, 435/93.1, 435/69.1, 435/69.2, 435/6, 435/7.1, 530/350, 536/23.1US Class Current435/6.17CPC Class CodesA61P 35/04 specific for metastasisA61P 43/00 Drugs for specific purposes...A61P 7/00 Drugs for disorders of the ...A61P 7/04 Antihaemorrhagics; Procoagu...C04B 35/5935 obtained by gas pressure si...C07K 14/8114 Kunitz type inhibitors
