Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
DCFirst Claim
1. A semiconductor nanocrystal compound, comprising:
- a) a water-soluble semiconductor nanocrystal comprising;
i) a core comprising a first semiconductor material; and
ii) a core-overcoating shell comprising a second semiconductor material; and
b) a linking agent linked to said water-soluble semiconductor nanocrystal and capable of linking to an affinity molecule.
2 Assignments
Litigations
0 Petitions
Reexamination
Accused Products
Abstract
A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in he probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
-
Citations
26 Claims
-
1. A semiconductor nanocrystal compound, comprising:
-
a) a water-soluble semiconductor nanocrystal comprising;
i) a core comprising a first semiconductor material; and
ii) a core-overcoating shell comprising a second semiconductor material; and
b) a linking agent linked to said water-soluble semiconductor nanocrystal and capable of linking to an affinity molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A luminescent semiconductor nanocrystal compound, comprising:
-
a) a water-soluble luminescent semiconductor nanocrystal comprising;
i) a core comprising a first semiconductor material; and
ii) a core-overcoating shell comprising a second semiconductor material; and
b) a linking agent linked to said water-soluble luminescent semiconductor nanocrystal and capable of linking to an affinity molecule.
-
-
24. A luminescent semiconductor nanocrystal compound, comprising:
-
a) a water-soluble luminescent semiconductor nanocrystal comprising;
i) a core comprising a first luminescent semiconductor nanocrystal material; and
ii) a core-overcoating shell comprising a second semiconductor material; and
b) a linking agent linked to said water-soluble luminescent semiconductor nanocrystal and capable of linking to an affinity molecule.
-
-
25. A luminescent semiconductor nanocrystal compound, comprising:
-
a) a water-soluble luminescent semiconductor nanocrystal comprising;
i) a core comprising a first semiconductor material; and
ii) a core-overcoating shell comprising a second luminescent semiconductor nanocrystal material; and
b) a linking agent lined to said water-soluble luminescent semiconductor nanocrystal and capable of linking to an affinity molecule.
-
-
26. A luminescent semiconductor nanocrystal compound, comprising:
-
a) a water-soluble luminescent semiconductor nanocrystal comprising;
i) a core comprising a first luminescent semiconductor nanocrystal material; and
ii) a core-overcoating shell comprising a second luminescent semiconductor nanocrystal material; and
b) a linking agent linked to said water-soluble luminescent semiconductor nanocrystal and capable of linking to an affinity molecule.
-
Specification