Glucose monitor calibration methods
First Claim
1. A method of calibrating glucose monitor data, the method comprising the steps of:
- sampling glucose monitor data at a predetermined rate from a glucose sensor over a period of time;
deriving at least one glucose monitor data point from the sampled glucose monitor data at a predetermined memory storage rate;
obtaining at least one blood glucose reference reading from a blood glucose measuring device that corresponds with the at least one glucose monitor data point;
calculating a calibration factor using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and
interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration factor post process.
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Abstract
A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.
1524 Citations
51 Claims
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1. A method of calibrating glucose monitor data, the method comprising the steps of:
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sampling glucose monitor data at a predetermined rate from a glucose sensor over a period of time;
deriving at least one glucose monitor data point from the sampled glucose monitor data at a predetermined memory storage rate;
obtaining at least one blood glucose reference reading from a blood glucose measuring device that corresponds with the at least one glucose monitor data point;
calculating a calibration factor using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and
interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration factor post process. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of calibrating glucose monitor data, the method comprising the steps of:
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sampling glucose monitor data from a sensor;
deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate;
deriving, at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate;
obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point;
determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and
calibrating the sampled glucose monitor data using the calibration equation. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. An apparatus to calibrate glucose monitor data, the apparatus comprising:
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means for sampling glucose monitor data;
means for deriving at least one glucose monitor data reading from the sampled glucose monitor data at a determined memory storage rate, means for obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data reading;
means for determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data reading; and
means for interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration equation post process.
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39. An article of manufacture containing code for calibrating glucose monitor data, comprising a computer usable media including at least one embedded computer program that is capable of causing at least one computer to perform:
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sampling glucose monitor data from a sensor;
deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate;
deriving at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate;
obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point;
determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and
calibrating the sampled glucose monitor data using the calibration equation. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A method of calibrating characteristic monitor data, the method comprising the steps of:
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sampling characteristic monitor data;
deriving interval values by applying clipping limits and averaging the post-clipped sampled characteristic monitor data over a predetermined interval rate;
deriving at least one characteristic monitor data point by averaging the derived interval values at a predetermined memory storage rate;
obtaining from another characteristic measuring device at least one characteristic reference reading that is temporally associated with at least one characteristic monitor data point;
calculating calibration characteristics using the at least one characteristic reference reading and the corresponding at least one characteristic monitor data point; and
calibrating the obtained characteristic monitor data using the calibration characteristics. - View Dependent Claims (50, 51)
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Specification