Ocular treatment device

• US 6,425,888 B1
• Filed: 08/11/1997
• Issued: 07/30/2002
• Est. Priority Date: 08/30/1994
• Status: Expired due to Fees

• Current Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Original Assignee: R.P. Scherer Corporation (Cardinal Health, Inc.)
• Inventors: Jones, Stephen P., Houzego, Peter J., Martini, Luigi G., Embleton, Jonathan K., Stevens, Howard N., Malcolmson, Richard J., Rocca, Sarah A.
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): Cho, David J.
• Application Number:
  US08/793,299
• Time in Patent Office: 1,814 Days
• Field of Search: 604/290, 604/294, 604/295, 604/296, 604/297, 222/94, 222/103, 222/541, 206/221, 206/484
• US Class Current: 604/290
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: B05B 9/0805 comprising a pressurised or compressible container for liquid or other fluent material B05B9/085 takes precedence
• CPC Class Codes: B65D 75/58 Opening or contents-removing devices added or incorporated during package manufacture B65D75/36, B65D85/1027 take precedence

Abstract

A unit container for a treatment fluid comprises a sealed enclosure of which one wall section thereof is formed with at least one opening. The enclosure is pressuriseable to discharge its contents through the opening or openings, which is or are of sufficient diameter to enable the generation of a jet and/or discrete droplets of treatment fluid discharged therefrom. The one wall section is typically a flat section of the enclosure wall, and the enclosure is typically a blister pack, with the wall section at a planar base of the blister. However, the one wall section may be dome-shaped and formed with at least one opening in the top region of the dome. Containers of the invention may be provided in packages, for example in strip form or in planar arrays. Dispensing devices are described for discharging their contents in treatment.

Claims

1. A method for delivery of a small amount of a treatment liquid to a target site, comprising

a. confining the liquid in a sealed and pressurizable enclosure, forming a unit container, the enclosure having at least one opening in a wall section thereof, said opening having a minimum diameter of at least 10 micrometers and being arranged to enable generation of a jet and/or droplets of the liquid discharged therefrom, the jet and/or droplets having a diameter no smaller than 20 micrometer,

b. positioning and targeting the enclosure adjacent the target site such that there is a spacing between the opening and the target site,

c. pressurizing the enclosure to discharge substantially all of its content through the opening in the form of a jet and/or droplets, the jet and/or droplets having a diameter no smaller than 20 micrometers and sufficient linear momentum to traverse the spacing both from above and horizontally or vertically upwards for impact on the target site.

2. The method of claim 1 wherein the jet and/or droplets forms a collinear stream.

3. The method of claim 1 wherein the pressurizing substantially evacuates the entire enclosure.

4. The method of claim 1 wherein the enclosure confines a unit does no more than 10 microliters.

5. The method of claim 1 wherein the target site is an eye.

6. The method of claim 5 wherein the jet and/or droplets have sufficient delivery rate to defeat the blink response.

7. The method of claim 5 wherein the positioning further includes locating a cowling, attached to the enclosure, so as to ensure a proper spacing to the eye.

8. A method according to claim 1 wherein the enclosure is pressurized by collapse of the wall thereof.

9. A method according to claim 8, wherein the wall includes a reinforced region to orient its collapse.

10. A method according to claim 9 wherein the enclosure is pressurized by the relative movement of at least one wall thereof.

11. A method according to claim 10 wherein the enclosure is a blister pack.

12. A method according to claim 11 wherein the liquid is discharged through the opening in a flat section of the enclosure wall.

13. A method according to claim 12 wherein the wall section is at a planer base of the blister.

14. A method according to claim 13 further including removing a cover overlaying said wall section and the opening therein.

15. A method according to claim 1 wherein the opening is closed by a membrane, which membrane ruptures upon pressurization of the enclosure.

16. A method according to claim 15 wherein the treatment liquid is an ophthalmic treatment fluid.

17. A method according to claim 16 wherein the sealed enclosure is one of a plurality thereof connected by a common supporting substrate, and further including locating one of the containers at a dosing station prior to discharging treatment liquid therefrom.

18. A method according to claim 17 wherein the locating a container at a dosing station is synchronized with the removal of the cover.

19. A method according to 18 claim wherein the enclosure is pressurized by compressing the enclosure from the outside and against the wall section thereof.

20. A method according to claim 19 wherein the enclosure is pressurized by a piston or hammer mechanism for urging towards the wall section of the enclosure an opposite section of the wall.

21. A method according to claim 19 wherein the enclosure is pressurized by a piezoelectric element.

22. A method according to claims 21 wherein the piezoelectric element is a ring transducer disposed around the enclosure.