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Polysaccharide sponges for cell culture and transplantation

  • US 6,425,918 B1
  • Filed: 11/17/1998
  • Issued: 07/30/2002
  • Est. Priority Date: 05/22/1996
  • Status: Expired due to Term
First Claim
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1. A polysaccharide sponge characterized by having:

  • (i) an average pore size in the range between about 10 μ

    m to about 300 μ

    m;

    (ii) an average distance between the pores being the wall thickness of the pores in the range between about 5 μ

    m to about 270 μ

    m; and

    (iii) an E-modulus of elasticity being a measure of the rigidity of the sponge in the range of about 50 kPa to about 500 kPa, wherein said sponge comprises an alginate selected from the group of alginates characterised by having;

    (i) a mannuronic acid (M) residue content in the range of between about 25% and about 65% of total residues;

    (ii) a guluronic acid (G) residue content in the range of between about 35% and about 75% of total residues;

    (iii) a M/G ratio of about ⅓ and

    about 1.86/1; and

    (iv) a viscosity of the final alginate solution having 1% w/v alginate, from which the sponge is obtained in the range between about 50 cP to about 800 cP.

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