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Orally administrable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent

  • US 6,426,087 B1
  • Filed: 08/22/2000
  • Issued: 07/30/2002
  • Est. Priority Date: 02/23/1998
  • Status: Expired due to Term
First Claim
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1. An orally administerable galenic formulation allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract, comprisingat least one active ingredient which is a guanidine or a guanylguanidine, an absorption-promoting agent having an HLB greater than 8 which is one or more lipid substances selected from polysorbates, ethers of polyoxyethylene and alkyl, esters of polyoxyethylene and fatty acids, fatty acids, fatty alcohols, bile acids and their salts with pharmaceutically acceptable cations, esters of C1-C6 alkanols with fatty acids, esters of polyol with fatty acids, wherein said polyol comprises 2 to 6 hydroxyl functional groups, and polyglycolysed glycerides, and one or more pharmaceutically acceptable excipients.

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