Radiopaque compositions for visualization of medical devices
First Claim
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1. A radiopaque polymeric composition having the formula wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and a halo;
- R1 and R3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
x is an integer from 1 to 1,000;
n is an integer from 1 to 1,000;
R2, R7, and R8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids;
R4, R5, and R6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons;
R9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl;
p is an integer from 1 to 100;
q is an integer from 1 to 100.
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Abstract
A radiopaque polymeric composition useful as a polymer coating on a substrate. The compositions are designed to be bioabsorbable and are particularly useful on implantable medical devices, such as vascular prostheses and the like.
160 Citations
24 Claims
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1. A radiopaque polymeric composition having the formula
wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and a halo; - R1 and R3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
x is an integer from 1 to 1,000;
n is an integer from 1 to 1,000;
R2, R7, and R8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids;
R4, R5, and R6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons;
R9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl;
p is an integer from 1 to 100;
q is an integer from 1 to 100. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- R1 and R3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
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10. A medical device having at least one radiopaque surface, said radiopaque surface comprising:
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a polymeric composition having the formula
wherein A is a substituted or unsubstituted aromatic or aliphatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato and halo;
R1 and R3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
x is an integer from 1 to 1,000;
n is an integer from 1 to 1,000;
R2, R7, and R8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids;
R4, R5, and R6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons;
R9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl;
p is an integer from 1 to 100;
q is an integer from 1 to 100.- View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A method of imparting a radiopaque polymeric coating to a surface of an article which comprises:
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a) contacting said surface with a radiopaque polymeric composition, said composition having the following formula;
wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
R1 and R3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo;
x is an integer from 1 to 1,000;
n is an integer from 1 to 1,000;
R2, R7, and R8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids;
R4, R5, and R6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons;
R9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl;
p is an integer from 1 to 100;
q is an integer from 1 to 100.- View Dependent Claims (19, 20, 21, 22, 23, 24)
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Specification
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Current AssigneeBoston Scientific Scimed (Boston Scientific Corporation)
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Original AssigneeScimed Life Systems Incorporated (Boston Scientific Corporation)
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InventorsMoroni, Antonio
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Primary Examiner(s)KILIMAN, LESZEK B
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Application NumberUS09/569,121Time in Patent Office810 DaysField of Search424/4, 424/5, 424/9, 424/9.4, 428/412, 428/423.1, 428/474.4, 428/480, 428/500US Class Current428/412CPC Class CodesA61K 49/0442 Polymeric X-ray contrast-en...A61K 49/0447 Physical forms of mixtures ...A61L 29/18 Materials at least partiall...A61L 31/18 Materials at least partiall...Y10T 428/31507 Of polycarbonateY10T 428/31551 Of polyamidoester [polyuret...Y10T 428/31725 Of polyamideY10T 428/31786 Of polyester [e.g., alkyd, ...Y10T 428/31855 Of addition polymer from un...
