Matrix-free osteogenic devices, implants and methods of use thereof
First Claim
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1. A device for inducing bone formation sufficient to fill a defect locus defining a void, the device comprising:
- an osteogenic protein dispersed in a biocompatible, nonrigid amorphous carrier having no defined surfaces, wherein said carrier is selected from the group consisting of poloxamers;
gelatins;
polyethylene glycols (PEG);
dextrins; and
vegetable oils;
with the proviso that said osteogenic protein is not TGF-β
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Abstract
Provided herein are methods for inducing bone formation in a mammal sufficient to fill a defect defining a void, wherein osteogenic protein is provided alone or dispersed in a biocompatible non-rigid, amorphous carrier having no defined surfaces. The methods and devices provide injectable formulations for filling critical size defects, as well as for accelerating the rate and enhancing the quality of bone formation in non-critical size defects.
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Citations
9 Claims
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1. A device for inducing bone formation sufficient to fill a defect locus defining a void, the device comprising:
an osteogenic protein dispersed in a biocompatible, nonrigid amorphous carrier having no defined surfaces, wherein said carrier is selected from the group consisting of poloxamers;
gelatins;
polyethylene glycols (PEG);
dextrins; and
vegetable oils;
with the proviso that said osteogenic protein is not TGF-β
.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
Specification