Use of β-lactamase inhibitors as neuroprotectants

• US 6,426,342 B2
• Filed: 02/13/2001
• Issued: 07/30/2002
• Est. Priority Date: 08/16/1999
• Status: Expired due to Term

• Current Assignee: Revaax Pharmaceuticals, LLC
• Original Assignee: Revaax Pharmaceuticals, LLC
• Inventors: Koppel, Gary A.
• Primary Examiner(s): Jarvis, William R. A.
• Application Number:
  US09/782,507
• Publication Number:
  US 20020002159A1
• Time in Patent Office: 532 Days
• Field of Search: 514/210.06, 514/192, 514/193, 514/210.1
• US Class Current: 514/210.06
• CPC Class Codes: A61K 31/424 condensed with heterocyclic ring systems, e.g. clavulanic acid
• CPC Class Codes: A61K 31/43 Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• CPC Class Codes: A61K 31/431 containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system

Abstract

Novel neuroprotectant methods are described. β-Lactamase inhibitors are used to prevent or reduce loss of neuronal cells and neuronal cell function in patients afflicted with or susceptible to disease states or conditions known to result in or cause neuronal tissue insult.

Claims

1. A method of treatment of a patient suffering from or susceptible to a condition known to result in loss of neuronal cells or loss of neuronal cell function by reducing neuronal cell loss or function resulting from such condition said method comprising the step of administering to said patient a neuroprotective amount of a bacterial β

-lactamase inhibitor.

2. A method for preventing neurons damage or the progression of neuronal damage in a patient suffering from or susceptible to disease states causing such neuronal damage, said method comprising the step of administering to the patient a neuroprotective amount of a bacterial β

-lactamase inhibitor.

3. A method of treatment of a patient suffering from or susceptible to a condition known to result in or from loss of neuronal cells or loss of neuronal cell function by reducing loss of neuronal cells or neuronal cell function resulting from such condition, said method comprising the step of administering to said patient a neuroprotective amount of clavulanic acid, a pharmaceutically acceptable salt thereof, or an active ester thereof.

4. A method for preventing neuronal damage or the progression of neuronal damage in a patient suffering from or susceptible to such neuronal damage, said method comprising the step of administering to said patient a neuroprotective amount of clavulanic acid, a pharmaceutically acceptable salt thereof, or an active ester thereof.