Delivery of ultrasound to percutaneous and intrabody devices

• US 6,428,491 B1
• Filed: 12/23/1999
• Issued: 08/06/2002
• Est. Priority Date: 08/27/1999
• Status: Expired due to Fees

• Current Assignee: Dan Weiss
• Original Assignee: Dan Weiss
• Inventors: Weiss, Dan
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/471,364
• Time in Patent Office: 957 Days
• Field of Search: 601/2-4, 604/264, 604/266, 604/267, 604/268, 604/269, 604/19, 604/22
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/3421 Cannulas
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61M 2205/058 with ultrasound therapy
• CPC Class Codes: A61M 25/0111 Aseptic insertion devices
• CPC Class Codes: A61M 25/02 Holding devices, e.g. on the body
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps

Abstract

A method and apparatus for reducing morbidity associated with a medical device inserted into the body of a patient. Ultrasonic energy is applied to the device with sufficient intensity to inhibit accretion of biological matter associated with the device while the device is in the body. Typically, the energy is applied to the device in the absence of clinically-observable accretion of biological matter on the device so as to prevent such accretion.

Claims

1. A method for reducing morbidity associated with an elongate medical device inserted into the body of a patient, comprising:

coupling an ultrasonic transducer to a portion of the elongate device that is outside the body, said portion having a longitudinal axis so that the transducer is approximately parallel to said longitudinal axis of the device; and

applying ultrasonic energy to the device by actuating the transducer so as to impart vibration to the device with sufficient intensity to inhibit accretion of biological matter associated with the device while the device is in the body.

2. A method according to claim 1, wherein applying the ultrasonic energy comprises applying energy to the device so as to inhibit bacterial growth on the device.

3. A method according to claim 1, wherein applying the ultrasonic energy comprises applying energy to inhibit formation of a clot on the device.

4. A method according to claim 1, and comprising administering a therapeutic agent in conjunction with applying the ultrasonic energy.

5. A method according to claim 4, wherein the therapeutic agent comprises an antibacterial agent.

6. A method according to claim 4, wherein the therapeutic agent comprises an anti-coagulant or fibrinolytic agent.

7. A method according to claim 4, wherein administering the therapeutic agent comprises coating at least a portion of the device with the therapeutic agent.

8. A method according to claim 4, wherein administering the therapeutic agent comprises administering the agent systemically.

9. A method according to claim 1, wherein the transducer comprises a bending-type transducer.

10. A method according to claim 1, wherein the transducer comprises a transverse-type transducer.

11. A method according to claim 1, wherein actuating the transducer comprises vibrating the device in a direction perpendicular to the axis.

12. Apparatus for reducing morbidity associated with an elongate device inserted into the body of a patient, comprising an ultrasonic transducer, which is adapted to be coupled to a portion of the elongate device that is outside the body said portion having a longitudinal axis so that the transducer is approximately parallel to said longitudinal axis of the device, so as to apply ultrasonic vibration to the device with sufficient intensity to inhibit accretion of biological matter associated with the device while the device is in the body.

13. Apparatus according to claim 12, wherein the ultrasonic energy inhibits bacterial growth on the device.

14. Apparatus according to claim 12, wherein the ultrasonic energy inhibits formation of a clot on the device.

15. Apparatus according to claim 12, wherein the ultrasonic energy is applied in conjunction with administration of a therapeutic agent.

16. Apparatus according to claim 12, and comprising an integrated circuit module, which drives the transducer so as to control one or more parameters of the energy applied to the device.

17. Apparatus according to claim 16, wherein the integrated circuit module generates an oscillating electrical current to drive the transducer, and wherein the module adjusts a frequency of the oscillating current so as to match a resonant frequency of the transducer.

18. Apparatus according to claim 16, wherein the integrated circuit module is coupled to the transducer by a connector, so that a first portion of the apparatus containing the transducer may be separated after use from a second portion including the integrated circuit module.

19. Apparatus according to claim 18, wherein the first portion of the apparatus is disposed of after use, while the second portion is reused.

20. Apparatus according to claim 12, wherein the transducer comprises a bendingtype transducer.

21. Apparatus according to claim 12, wherein the transducer comprises a transverse-type transducer.

22. Apparatus according to claim 12, wherein the transducer is coupled to the device so as to cause vibration of the device in a direction perpendicular to the axis.

23. An ultrasonic energy generator for use with an elongate invasive medical device, comprising:

a ultrasonic energy generator, adapted to be mechanically coupled to a proximal portion of the invasive device that is outside the body said portion having a longitudinal axis; and

a transducer, held approximately parallel to a longitudinal axis of the device by the generator body so as to apply ultrasonic vibration to the invasive device while a distal portion of the device is in the body.

24. A generator according to claim 23, wherein application of the ultrasonic energy inhibits accretion of biological matter associated with the device.

25. A generator according to claim 23, wherein the generator body comprises a fastener, which is adapted to fix the transducer to the invasive device.

26. A generator according to claim 23, wherein the transducer comprises a bending-type transducer.

27. A generator according to claim 23, wherein the transducer comprises a transverse-type transducer.

28. A generator according to claim 23, wherein the transducer is coupled to the device so as to cause vibration of the device in a direction perpendicular to the axis.

29. A medical device, comprising:

an elongate intrabody member having a longitudinal axis, for insertion into the body of a patient; and

an ultrasonic transducer, which is coupled to the intrabody member so that the transducer is approximately parallel to the longitudinal axis, so as to apply ultrasonic vibration to the intrabody member with sufficient intensity to inhibit accretion of biological matter associated with the device while the device is in the body.

30. A device according to claim 29, wherein the intrabody member comprises a catheter.

31. A device according to claim 29, wherein the transducer comprises a bendingtype transducer.

32. A device according to claim 29, wherein the transducer comprises a transverse-type transducer.

33. A device according to claim 29, wherein the transducer is coupled to cause vibration of the intrabody member in a direction perpendicular to the axis.