Selective tissue targeting by difference frequency of two wavelengths

• US 6,428,532 B1
• Filed: 12/14/1999
• Issued: 08/06/2002
• Est. Priority Date: 12/30/1998
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Lee, Shun, Doukas, Apostolos
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): FARAH, AHMED M
• Application Number:
  US09/460,860
• Time in Patent Office: 966 Days
• Field of Search: 606/3, 606/8-10, 606/13, 606/27, 606/131, 606/41, 606/43, 606/49, 607/88, 607/89, 607/96, 607/97, 128/898, 359/245-249, 359/251, 359/264, 359/325, 359/326, 359/349, 372/21, 372/22
• US Class Current: 606/9
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2018/207 mixing two wavelengths
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A method and apparatus for treating tissue directs first and second wavelengths of energy, e.g., laser or ultrasonic signal energy, into an overlap region of tissue such that the first and second wavelengths mix in situ to form a third wavelength. The third wavelength effectively couples energy into the tissue to treat tissue in said overlap region, producing local heating or cavitation. Wavelengths may be selected such that overlying tissue is unharmed, and the two wavelengths may be applied along different paths and cross in the overlap region. Absorbers or dyes may be used to tailor absorbance of the third wavelength. When using ultrasonic energy, signals of several megahertz may be so mixed to provide a lower frequency treatment signal such as a 200 kHz treatment signal or a subharmonic. Laser signals may be mixed to form a treatment signal in the infrared.

Claims

1. An apparatus for treating tissue using two different wavelengths, comprising a first energy emitter which produces a first wavelength of energy and a second energy emitter which produces a second wavelength of a second energy, such that said first and second wavelengths are focused onto a focal point or region of a tissue, such that said first and second wavelengths produce an overlap region in which the first and second wavelengths mix to form a third wavelength which produces cavitation and/or hyperthermia at said focal point or region within said tissue.

2. The apparatus of claim 1, wherein said first and second energy emitters are lasers.

3. The apparatus of claim 2, wherein said lasers are ND:

YAG lasers.

4. The apparatus of claim 2, wherein said piezoelectric transducers are ceramic.

5. The apparatus of claim 1, wherein said first wavelength is about 1.06 μ

m and said second wavelength is between about 550 nm and 920 nm.

6. The apparatus of claim 1, wherein said energy difference is between about 3 and 6.5 μ

m.

7. The apparatus of claim 1, wherein said first and second energy emitters are piezoelectric transducers.

8. The apparatus of claim 1, wherein said first wavelength of energy has a frequency of about 3.8 MHZ and said second wavelength of energy has a frequency of about 4.0 MHZ.

9. The apparatus of claim 1, wherein said two different wavelengths of energy are ultrasonic signals having a frequency difference of about 200 kHz.

10. The apparatus of claim 9, wherein said wavelengths mix to form a signal with a subharmonic frequency of about 100 kHz.

11. An apparatus for treating tissue using two different wavelengths, comprising

a) a first energy emitter which produces a first wavelength of energy;

b) a second energy emitter which produces a second wavelength of a second energy; and

c) a control means for said apparatus to carry out treatment, wherein said control means causes transmission and focusing of said first and second wavelengths onto a focal point or region of a tissue, whereby said first and second wavelengths produce an overlap region having an energy difference which produces energy of a third wavelength effective to provide cavitation an/or hyperthermia at said focal point or region within said tissue.

12. The apparatus of claim 11, wherein said control means causes transmission of ultrasonic waves for a duration of between about 1 millisecond and continuous.

13. The apparatus of claim 11, wherein said control means provides transmission of ultrasonic waves by successive pulses.

14. A method for treating tissue using two different wavelengths, comprising the steps of:

a) directing a first wavelength of energy into a tissue; and

b) directing a second wavelength of a second energy into said tissue, such that said first and second wavelengths are focused onto a focal point or region of said tissue in an overlap region having an energy difference which produces a third wavelength that effectively couples energy to said tissue to provide cavitation and/or hyperthermia at said focal point or region within said tissue, thereby treating said tissue.

15. The method of claim 14, wherein the steps of directing said first and second wavelengths of energy are performed by directing lasers.

16. The method of claim 15, wherein said lasers are ND:

YAG lasers.

17. The method of claim 14, wherein said first wavelength is about 1.06 μ

m and said second wavelength is between about 558 nm and 920 nm.

18. The method of claim 14, wherein said energy difference is between about 3 and 6.5 μ

m.

19. The method of claim 14, wherein said first and second energy emitters are piezoelectric transducers.

20. The method of claim 19, wherein said piezoelectric transducers are ceramic.

21. The method of claim 14, wherein said first wavelength is about 3.8 MHZ and said second wavelength is about 4.0 MHZ.

22. The method of claim 14, wherein said energy difference is about 200 kHz.

23. The method of claim 22, wherein said energy difference has a subharmonic frequency of about 100 kHz.

24. The method of claim 14, wherein said energy wavelengths are pulsed for a duration of between about 1 millisecond and continuous.

25. A method of treating tissue, such method comprising the step of directing first and second wavelengths of energy into an overlap region of tissue such that the first and second wavelengths mix in situ to form a third wavelength, wherein the third wavelength effectively couples energy into the tissue to treat tissue in said overlap region.