Electrophysiological treatment methods and apparatus employing high voltage pulse to render tissue temporarily unresponsive

• US 6,428,537 B1
• Filed: 05/22/1998
• Issued: 08/06/2002
• Est. Priority Date: 05/22/1998
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Swanson, David K., Whayne, James G.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US09/083,874
• Time in Patent Office: 1,537 Days
• Field of Search: 606/41, 606/42, 606/45, 607/100-102, 607/122, 600/374, 600/508, 600/510
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00095 high, i.e. heat conducting
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]

Abstract

Systems and methods for diagnosing and treating tissue transmit an electrical energy pulse that temporarily stuns a zone of tissue, temporarily rendering it electrically unresponsive. The systems and methods sense an electrophysiological effect due to the transmitted pulse. The systems and methods alter an electrophysiological property of tissue in or near the zone based, at least in part, upon the sensed electrophysiological effect. The alteration of the electrophysiological property can be accomplished, for example, by tissue ablation or by the administration of medication. In a preferred implementation, radio frequency energy is used to both temporarily stun tissue and to ablate tissue through a common electrode.

Claims

1. An electrophysiological system, comprising:

an apparatus that modifies tissue; and

an apparatus that generates and transmits an electrical energy pulse that temporarily renders a zone of tissue electrically unresponsive.

2. A system as claimed in claim 1, wherein the apparatus that modifies tissue comprises an ablation device.

3. A system as claimed in claim 1, wherein the apparatus that generates and transmits an electrical energy pulse comprises a three-dimensional support structure and a plurality of electrodes on the support structure.

4. A system as claimed in claim 1, wherein the apparatus that modifies tissue and the apparatus that generates and transmits an electrical energy pulse together comprise at least one electrode, a source of ablation energy connected to the at least one electrode, and a source of energy that renders tissue temporarily unresponsive.

5. A system as claimed in claim 1, wherein the electrical energy pulse renders the zone of tissue electrically unresponsive for at least one second.

6. A system as claimed in claim 1, wherein the apparatus that generates and transmits an electrical energy pulse comprises an electrode and a source of energy that renders tissue temporarily unresponsive.

7. A system as claimed in claim 6, wherein the source of energy that renders tissue temporarily unresponsive comprises a source of energy that renders tissue temporarily unresponsive for at least one second.

8. A system as claimed in claim 6, wherein the apparatus that generates and transmits an electrical energy pulse further comprises a support body and the electrode is supported on the support body.

9. A system as claimed in claim 8, wherein the support body comprises a catheter body.

10. A system as claimed in claim 8, wherein the support body comprises a relatively short shaft.

11. An electrophysiological system, comprising:

an apparatus that generates and transmits an electrical energy pulse that temporarily renders a zone of tissue having a first predetermined depth electrically unresponsive for at least one second; and

an apparatus adapted to sense an electrophysiological effect due to the transmitted pulse.

12. A system as claimed in claim 11, wherein the apparatus that generates and transmits an electrical energy pulse is adapted to transmit a second electrical energy pulse that temporarily renders a zone of tissue having a second predetermined depth electrically unresponsive, the second predetermined depth being greater than the first predetermined depth.

13. A system as claimed in claim 11, wherein the apparatus that generates and transmits an electrical energy pulse comprises an electrode and a source of energy that renders tissue temporarily unresponsive for at least one second.

14. A system as claimed in claim 13, wherein the apparatus that generates and transmits an electrical energy pulse further comprises a support body and the electrode is supported on the support body.

15. A system as claimed in claim 14, wherein the support body comprises a catheter body.

16. A system as claimed in claim 14, wherein the support body comprises a relatively short shaft.

17. A system for modifying tissue, comprising:

a support body;

at least one electrode on the support body; and

an energy generator that supplies pulses of energy to the at least one electrode with a voltage high enough to kill tissue by dielectric breakdown and for a period sufficient to kill the tissue and insufficient to vaporize the tissue.

18. A system as claimed in claim 17, wherein the voltage of the pulses is about 4000 volts.

19. A system as claimed in claim 17, wherein period is between about 0.1 milliseconds and about 1000 milliseconds.