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Preparing artificial organs by forming polylayers of different cell populations on a substrate

  • US 6,428,802 B1
  • Filed: 12/29/1999
  • Issued: 08/06/2002
  • Est. Priority Date: 12/29/1999
  • Status: Expired due to Term
First Claim
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1. An artificial organ construct comprising:

  • a biocompatable substrate;

    a first cultured polylayer of cells derived from an isolated population of smooth muscle cells on the biocompatible substrate; and

    a second cultured polylayer of cells derived from a second cell population that is different from the smooth muscle cell population, wherein the second polylayer is coupled to the first polylayer at a boundary between the first and second polylayer such that the construct provides the functional equivalent of a natural biological structure upon implantation.

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