Pharmacological drug combination in vagal-induced asystole
First Claim
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1. A method of preparing a patient for asystole, comprising administration to the patient of an amount of a pharmaceutical composition comprising an acetylcholinesterase inhibitor, a β
- -adrenergic receptor blocker, and a calcium channel blocker, wherein the amount of the composition is effective to produce cardiac asystole upon stimulation of one or both vagus nerves.
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Abstract
Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs.
156 Citations
25 Claims
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1. A method of preparing a patient for asystole, comprising administration to the patient of an amount of a pharmaceutical composition comprising an acetylcholinesterase inhibitor, a β
- -adrenergic receptor blocker, and a calcium channel blocker, wherein the amount of the composition is effective to produce cardiac asystole upon stimulation of one or both vagus nerves.
- View Dependent Claims (4)
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2. A method for achieving controlled cardiac asystole in a patient, comprising administration to the patient of a pharmaceutical composition comprising an acetylcholinesterase inhibitor, a β
- -adrenergic receptor blocker, and a calcium channel blocker, and stimulation of one or both vagus nerves.
- View Dependent Claims (3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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