Use of taurolidine to treat tumors
First Claim
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1. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said tumor cell is a urinary bladder carcinoma.
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Abstract
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
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Citations
22 Claims
- 1. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said tumor cell is a urinary bladder carcinoma.
- 3. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said tumor cell is a malignant skin cell.
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7. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said tumor cell is a liver cancer.
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8. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said composition is administered by infusion into a blood vessel of the liver.
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9. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said composition is administered by infusion into the hepatic artery.
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10. A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface of said tumor cell at a dose sufficient to induce tumor cell death by apoptosis, wherein said composition is administered by infusion into the portal vein.
- 11. A method of purging a population of bone marrow cells of tumor cells ex vivo, comprising contacting said population with a composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
- 16. A method of purging a population of peripheral blood mononuclear cells of tumor cells, comprising contacting said population with a composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
- 20. A therapeutic film-forming composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
Specification