NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production

• US 6,430,960 B1
• Filed: 08/23/2001
• Issued: 08/13/2002
• Est. Priority Date: 06/30/1999
• Status: Expired due to Fees

• Current Assignee: Polarean, Inc. (Polarean Imaging Plc)
• Original Assignee: Medi-Physics Incorporated (General Electric Company)
• Inventors: Driehuys, Bastiaan
• Primary Examiner(s): CAPOSSELA, RONALD C
• Application Number:
  US09/938,247
• Publication Number:
  US 20020066287A1
• Time in Patent Office: 355 Days
• Field of Search: 165/61, 637/637
• US Class Current: 62/637
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002

Abstract

Hyperpolarizers which produce hyperpolarized noble gases include one or more on-board NMR monitoring coils configured to monitor the polarization level of the hyperpolarized gas at various production points in the polarized gas production cycle. A dual symmetry NMR coil is positioned adjacent the optical pumping cell and is in fluid communication with a secondary reservoir in fluid communication with the polarized gas dispensing or exit flow path. This can measure the post-thaw polarization of the gas “on-board” the polarizer. Alternately or additionally, a NMR monitoring coil is assembled to the exit port portion of the optical pumping cell to give a more reliable indication of the polarization level of the gas as it flows out of the gas optical pumping cell. Another NMR monitoring coil can be positioned in a cryogenic bath adjacent a quantity of frozen polarized ¹²⁹Xe to determine the polarization level of the frozen gas.

Claims

1. A method for releasing the post-thaw cryogenically accumulated hyperpolarized gas from a cold finger collection container operably associated with exit flow path plumbing, comprising the steps of:

cryogenically accumulating a quantity of hyperpolarized gas as a frozen sample in a cold finger;

monitoring a pressure associated with the cryogenically collected hyperpolarized gas sample held in the cold finger;

thawing at least a portion of the quantity of frozen hyperpolarized gas sample in the cold finger;

increasing the pressure in the cold finger, thereby facilitating the phase transition of the hyperpolarized gas from a substantially frozen sample into a thawed fluid sample; and

releasing the thawed fluid hyperpolarized sample as a gas from the cold finger responsive to when the hyperpolarized sample achieves a predetermined pressure based on the pressure determined during said monitoring step.

2. A method according to claim 1, wherein a major portion of said hyperpolarized gas transitions from a frozen solid sample into a liquid phase corresponding to the pressure in said cold finger during said thawing step, wherein the hyperpolarizer is configured with exit flow path plumbing disposed downstream of and in fluid communication with the cold finger, and wherein said releasing step is in response to the opening of a valve downstream of the cold finger in the hyperpolarizer.

3. A method according to claim 2, wherein said thawing and releasing steps are performed while the cold finger is held in position on the hyperpolarizer and in fluid communication with the exit flow path plumbing.

4. A method according to claim 2, wherein the cold finger includes two spaced apart shut off valves associated therewith, at least one of which is open during the thawing step.

5. A method according to claim 1, wherein said hyperpolarized gas sample comprises hyperpolarized ¹²⁹Xe.

6. A method according to claim 1, wherein the hyperpolarizer is configured with exit flow path plumbing disposed downstream of and in fluid communication with the cold finger, and wherein said monitoring step is carried out by monitoring the pressure downstream of the cold finger in the exit flow path plumbing.

7. A method according to claim 6, wherein said exit flow path plumbing comprises a plurality of valves, and wherein said releasing step is carried out in response to the opening of a valve downstream of the cold finger in the exit flow path plumbing, and wherein the predetermined pressure is at least about 1 atm.

8. A method of releasing post-thaw cryogenically accumulated hyperpolarized gas from a cold finger collection container associated with exit flow path plumbing, comprising the steps of:

cryogenically accumulating a quantity of hyperpolarized gas as a frozen sample in a cold finger;

monitoring a pressure associated with the cryogenically collected hyperpolarized gas sample held in the cold finger;

thawing at least a portion of the quantity of frozen hyperpolarized gas sample in the cold finger;

increasing the pressure in the cold finger to facilitate the phase transition of the hyperpolarized gas from a substantially frozen sample into a thawed sample;

storing the thawed sample in fluid connection with the cold finger;

measuring the pressure associated with the cryogenically collected hyperpolarized gas during the thawing and storing steps, said measuring step measuring the pressure at a location in the exit flow path plumbing which is located downstream of the cold finger; and

releasing the thawed sample as a gas from the cold finger when the measured pressure reaches a predetermined value as determined by said step of measuring.

9. A method according to claim 8, wherein a major portion of said hyperpolarized gas transitions from a frozen solid sample directly into a liquid phase corresponding to the pressure in said cold finger during said thawing step, and wherein said releasing step is in response to the opening of a valve downstream of the cold finger in the hyperpolarizer and wherein the predetermined pressure is at least about 1 atm.

10. A method according to claim 8, wherein the cold finger has two spaced apart shut off valves associated therewith, at least one of which is open during the thawing step.

11. A method according to claim 8, wherein said hyperpolarized gas sample comprises hyperpolarized ¹²⁹Xe.