Automated liquid manufacturing system

• US 6,432,143 B2
• Filed: 02/23/2001
• Issued: 08/13/2002
• Est. Priority Date: 05/16/1997
• Status: Expired due to Term

• Current Assignee: Life Technologies Incorporated (Thermo Fisher Scientific Incorporated)
• Original Assignee: Life Technologies Incorporated (Thermo Fisher Scientific Incorporated)
• Inventors: Kubiak, James M., Battistoni, Todd A., Jayme, David W.
• Primary Examiner(s): Soohoo, Tony G.
• Application Number:
  US09/790,623
• Publication Number:
  US 20010006485A1
• Time in Patent Office: 536 Days
• Field of Search: 366/152.1, 366/177.1, 366/173.1, 366/174.1, 366/178.1, 366/179.1, 366/348, 366/336, 366/152.4, 222/1, 222/145.5, 222/145.6, 137/2, 137/3, 137/5, 422/189, 422/193, 422/194, 422/196
• US Class Current: 366/173.1
• CPC Class Codes: B01F 2025/916 Turbulent flow, i.e. every point of the flow moves in a random direction and intermixes
• CPC Class Codes: B01F 2101/44 Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
• CPC Class Codes: B01F 23/405 Methods of mixing liquids with liquids B01F23/4105 takes precedence
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 23/483 using water for diluting a liquid ingredient, obtaining a predetermined concentration or making an aqueous solution of a concentrate
• CPC Class Codes: B01F 23/49 Mixing systems, i.e. flow charts or diagrams
• CPC Class Codes: B01F 25/314 wherein additional components are introduced at the circumference of the conduit
• CPC Class Codes: B01F 25/431 Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
• CPC Class Codes: B01F 35/20 Measuring; Control or regulation
• CPC Class Codes: B01F 35/21 Measuring
• CPC Class Codes: B01F 35/2207 Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants B01F33/848 takes precedence
• CPC Class Codes: B01F 35/712 for feeding fluids
• CPC Class Codes: B01F 35/715 Feeding the components in several steps, e.g. successive steps
• CPC Class Codes: C12M 29/26 Conditioning fluids entering or exiting the reaction vessel
• CPC Class Codes: C12M 99/00 Subject matter not otherwise provided for in other groups of this subclass
• CPC Class Codes: Y10T 137/034 Controlled by conductivity of mixture
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A method and apparatus for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions to the diluent stream sufficiently in advance of one another so that adverse chemical reactions do not occur. The method also adjusts a pH level of the diluent prior to adding any of the concentrate solutions to the diluent.

Claims

1. A system for continuously preparing medium from concentrated solutions comprising:

a diluent system that provides a diluent;

a concentrate system that provides a plurality of chemically incompatible concentrate solutions; and

a medium mixing system that receives said diluent, that creates a turbulent diluent stream from said diluent, and that adds said plurality of concentrate solutions to said turbulent diluent stream in such a manner so that none of the ingredients of said plurality of concentrate solutions adversely chemically react with each other.

2. The system of claim 1, wherein said medium mixing system comprises:

a static mixing chamber that receives said diluent and that creates said turbulent diluent stream from said diluent; and

a plurality of injection ports incorporated into said static mixing chamber that adds said plurality of concentrate solutions to said turbulent diluent stream.

3. The system of claim 2, wherein said medium mixing system further comprises:

a pump associated with each of said plurality of injection ports for controlling a flow of said plurality of concentrate solutions into said static mixing chamber.

4. The system of claim 2, wherein a first of said plurality of injection ports adds a first concentrate solution into said static mixing chamber sufficiently in advance of a second of said plurality of injection ports adding a second concentrate solution into said static mixing chamber to prevent the ingredients of said first and second concentrate solutions from adversely chemically reacting with one another.

5. The system of claim 4, wherein said plurality of injection ports comprises:

a first plurality of injection ports radially disposed from one another around an approximate circumference of said static mixing chamber.

6. The system of claim 5, wherein said plurality of injection ports further comprises:

a second plurality of injection ports radially disposed from one another around an approximate circumference of said static mixing chamber and linearly disposed along a flow path of said static mixing chamber.

7. The system of claim 6, wherein said plurality of injection ports further comprises:

at least one injection port linearly disposed along a flow path of said static mixing chamber from said first and said second plurality of injection ports.

8. The system of claim 7, wherein said at least one injection port is linearly disposed upstream along the flow path from said first and said second plurality of injection ports.

9. The system of claim 6, wherein said first plurality of injection ports adds at least one of the set of an acid soluble concentrate solution, a group I salts concentrate solution, and a sodium hydroxide concentrate solution.

10. The system of claim 6, wherein said second plurality of injection ports add at least one of the set of a group II salts concentrate solution and a base soluble concentrate solution.

11. The system of claim 5, wherein said plurality of injection ports further comprises:

at least one injection port linearly disposed along a flow path of said static mixing chamber from said first plurality of injections ports.

12. The system of claim 11, wherein said at least one injection port is linearly disposed upstream along the flow path from said first plurality of injection ports.

13. The system of claim 12, wherein said at least one injection port adds a solution that adjusts a pH level of said turbulent diluent stream.

14. The system of claim 13, wherein said at least one injection port adds an acid solution to said turbulent diluent stream.

15. The system of claim 13, wherein said at least one injection port adds a caustic solution to said turbulent diluent stream.

16. The system of claim 5, wherein said first plurality of injection ports adds at least one of the set of an acid soluble concentrate solution, a group I salts concentrate solution, and a sodium hydroxide concentrate solution.

17. A system for continuously mixing aqueous solutions, comprising:

means for providing a flow controlled turbulent diluent stream;

means for adding a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream in such a manner that none of the ingredients of the concentrate solutions adversely chemically react with each other; and

means for forming a diluted mixture of said concentrate solutions.

18. The system of claim 17, wherein said means for adding further comprises:

means for adding a first of said chemically incompatible concentrate solutions to said turbulent diluent stream sufficiently in advance of the addition of a second of said chemically incompatible concentrate solutions to prevent the ingredients of said first and said second chemically incompatible concentrate solutions from adversely chemically reacting with each other.

19. The system of claim 18, wherein said means for adding further comprises:

means for adding said first of said chemically incompatible concentrate solutions to said turbulent diluent stream in a manner that is approximately radially disposed from the addition of said second of said chemically incompatible concentrate solutions to prevent the ingredients of said first and said second chemically incompatible concentrate solutions from adversely chemically reacting with each other.

20. The system of claim 19, wherein said means for adding a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream comprises:

means for adding a base soluble concentrate solution to said turbulent diluent stream in a manner that is approximately radially disposed from the addition of a group II salt concentrate solution so that none of the ingredients of said base soluble solution and said group II salt solution adversely chemically react with each other.

21. The system of claim 18, wherein said means for adding further comprises:

means for adding said first of said chemically incompatible concentrate solutions to said turbulent diluent stream linearly upstream of the addition of said second of chemically incompatible concentrate solutions to prevent the ingredients of said first and said second chemically incompatible concentrate solutions from adversely chemically reacting with each other.

22. The system of claim 21, wherein said means for adding a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream comprises:

means for adding an acid soluble concentrate solution to said turbulent diluent stream; and

means for adding a group II salt concentrate solution to said turbulent diluent stream at a position linearly disposed from the addition of said acid soluble concentrate solution in such a manner that none of the ingredients of said acid soluble concentrate solution and said group II salt concentrate solution adversely chemically react with each other.

23. The system of claim 18, further comprising:

means for adjusting a pH level of said turbulent diluent stream.

24. The system of claim 23, wherein said means for adjusting a pH level comprises:

means for adding an acid solution to said turbulent diluent stream to reduce said pH level.

25. The system of claim 23, wherein said means for adjusting a pH level comprises:

means for adding a caustic solution to said turbulent diluent stream to increase said pH level.

26. The system of claim 23, wherein said means for adjusting a pH level comprises:

means for adding an acid solution to said turbulent diluent stream to decrease said pH level; and

means for adding a caustic solution to said turbulent diluent stream to increase said pH level.

27. The system of claim 23, wherein said means for adjusting a pH level comprises:

means for adjusting a pH level of said turbulent diluent stream before said means for adding adds any of said plurality of chemically incompatible concentrate solutions to said turbulent diluent stream.

28. The system of claim 17, wherein said means for adding a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream comprises:

means for adding at least two of said plurality of chemically incompatible concentrate solutions to said turbulent diluent stream in such a manner that none of the ingredients of said at least two of said plurality of chemically incompatible concentrate solutions adversely chemically react with each other, wherein said plurality of chemically incompatible concentrate solutions include solutions from the set of;

an acid soluble concentrate solution subgroup, a group I salt concentrate solution subgroup, a group II salt concentrate solution subgroup, and a base soluble concentrate solution subgroup.