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Apparatus and method for trapping bead based reagents within microfluidic analysis systems

  • US 6,432,290 B1
  • Filed: 11/26/1999
  • Issued: 08/13/2002
  • Est. Priority Date: 11/26/1999
  • Status: Expired due to Term
First Claim
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1. A microfluidic analysis system, comprising:

  • (a) a substantially planar substrate having an upper surface;

    (b) at least one main channel formed into said upper surface, said main channel having first and second ends and a defined direction of flow in use;

    (c) a cover plate arranged over said planar substrate, said cover plate closing off said channel from above;

    (d) a first weir formed across said main channel and between said first and second ends of said channel, said first weir providing at least one flow gap to allow, in use, at least some fluid to flow past said first weir while trapping packing material having constituent particles that are generally larger than said flow gap; and

    (e) a second weir located upstream from said connected first end of said side channel, said first and second weirs forming a chamber therebetween, said second weir providing at least one flow gap to allow, in use, at least some fluid to flow past said second weir while trapping said packing material within said chamber.

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