Optochemical sensor

• US 6,432,363 B2
• Filed: 03/12/2001
• Issued: 08/13/2002
• Est. Priority Date: 09/15/1998
• Status: Expired due to Term

• Current Assignee: JOANNEUM RESEARCH Forschungsgesellschaft mbH (Province of Styria)
• Original Assignee: JOANNEUM RESEARCH Forschungsgesellschaft mbH (Province of Styria)
• Inventors: Reininger, Franz, Trettnak, Wolfgang, Biebernik, Karin
• Primary Examiner(s): SNAY, JEFFREY R
• Application Number:
  US09/802,971
• Publication Number:
  US 20010026775A1
• Time in Patent Office: 519 Days
• Field of Search: 422/82.05, 422/82.07, 422/82.08, 422/82.11, 250/458.1, 250/459.1
• US Class Current: 422/82.07
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 31/224 for investigating presence of dangerous gases
• CPC Class Codes: G01N 31/225 for oxygen, e.g. including dissolved oxygen

Abstract

The invention relates to an optochemical sensor consisting of a polymer matrix and a luminescent colorant material contained therein, whose emission power may be modified by the substances to be detected after being excited with electro-magnetic radiation. The polymer matrix is formed by at least one polymer, wherein no plasticizers have been added, which polymer contains phenyl groups in the main chain and may also be sterilized. the invention also relates to a method for producing the disclosed optochemical sensor, wherein a solution of a polymer is prepared, wherein 0.01 to 100 mMol luminescent colorant material per polymer is added to the solution and the mixture is solidified to obtain a homogenous membrane.

Claims

1. An optochemical sensor comprising a luminescent dye incorporated in a polymer matrix, the luminescent dye having an emission capacity which is variable upon excitation with electromagnetic radiation by a detectable substance;

the polymer matrix being formed, without plasticizer addition, of at least one polymer having a main chain containing phenyl groups, the polymer having a glass transition temperature of above 140°

C. and comprising at least one member selected from the group consisting of a polysulfone, a polyether sulfone, a polyether imide and a polyoxyphenylene.

2. An optochemical sensor according to claim 1 wherein the electromagnetic radiation is light.

3. An optochemical sensor according to claim 1 wherein the detectable substance is a member selected from the group consisting of gaseous or dissolved oxygen, gaseous or dissolved SO₂, gaseous or dissolved H₂O₂, gaseous or dissolved chlorine, a nitrogen oxide and a halogenated hydrocarbon.

4. An optochemical sensor according to claim 1, wherein the luminescent dye comprises from 0.01 to 100 mMol dye per kg of polymer.

5. An optochemical sensor according to claim 4 wherein the luminescent dye comprises from 0.1 to 20 mMol dye per kg of polymer.

6. An optochemical sensor according to claim 1, wherein the luminescent dye is stable up to a temperature of at least 150°

C. and is a member selected from the group consisting of an inorganic salt of a transition metal complex having an α

-diimine ligand, an inorganic salt of terpyridine, a transition metal complex of a porphyrine or of a porphyrine derivative, a polycyclic aromatic hydrocarbon and campherchinone.

7. An optochemical sensor according to claim 6 wherein the inorganic salt of a transition metal complex having an α

-diimine ligand is a member selected from the group consisting of a tris(4,7-diphenyl-1,10-phenanthroline) ruthenium(II) salt, a tris(1,10-phenanthroline) ruthenium (II) salt and a tris-2,2′

-bipyridyl ruthenium(II) salt;

the inorganic salt of terpyridine is osmium terpyridine;

the transition metal complex of a porphyrine or of a porphyrine derivative is a member selected from the group consisting of a complex of the tetraphenylporphyrine of Pt, a complex of the tetraphenylporphyrine of Pd, a complex of the octaethylporphyrine ketone of Pt, a complex of the octaethylporphyrine ketone of Pd, a complex of the tetrapentafluorophenylporphyrine of Pt, a complex of the tetrapentafluorophenylporphyrine of Pd, a complex of the octaethylporphyrine of Pt, and a complex of the octaethylporphyrine of Pd; and

the polycyclic aromatic hydrocarbon is a member selected from the group consisting of decacyclene, pyrene and a pyrene derivative.

8. An optochemical sensor according to claim 1 in combination with and on a substrate.

9. An optochemical sensor according to claim 8, wherein the substrate is an optically inactive light-permeable polymer that is insoluble in and resistant to a member selected from the group consisting of an organic solvent, an acid, a base and water.

10. An optochemical sensor according to claim 8 wherein the substrate is a member selected from the group consisting of polyester, polymethylmethacrylate and glass.

11. An optochemical sensor according to claim 10 wherein the polyester is PET.

12. An optochemical sensor according to claim 1 in combination with and covered by an optically insulating or protecting layer permeable to a substance to be analyzed.

13. An optochemical sensor according to claim 12, wherein the optically insulating layer comprises a member selected from the group consisting of coarsely porous polytetrafluoroethylene, a copolymer of 2,2-bis-trifluoromethyl-4,5-difluoro-1,3-dioxolene and tetrafluoroethylene, and silicone.