Limiting the presence of microorganisms using polymer-bound metal-containing compositions
First Claim
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1. A method for limiting the presence of a microorganism, the method comprising contacting the microorganism with a polymer-bound metal-containing composition comprising a compound having the following formula:
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wherein;
Z1 and Z2 each independently represent an arene nucleus, which has from 5 to 14 ring atoms;
G1 and G2 each independently represent a metal ligating group such that G1 and G2 may be contained within or pendant from at least one of Z1 and Z2;
R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkyl- or aryl sulfonyl group, an alkyl- or aryl sulfoxyl group, an aryloxyl group, a hydroxyl group, a thioarrido, a carbamoyl group, a sulfamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group;
L1 represents a nitrogen heterocycle substituted with R1 or R2 or both R1 and R2;
R1 and R2 each independently represent a polymer-bound group, a hydrogen, a halogen atom, an alkyl group, a vinyl group, a hydroxyalkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, an alkylthio group, an alkylamino group, an alkoxycarbonyl group, an acyloxy group, an alylsulfonyl group, an alkylsulfoxyl group, an alkylcarbamoyl group, an alkylsulfamoyl group, a formyl group, an acyl group, a silyl group, or a sulfoalkoxy group;
wherein at least one of R1 and R2 represents a polymer-bound group;
L2 represents a monodentate or polydentate ligand;
X represents nitrogen or a retained group;
M represents a platinum or palladium atom; and
k, m, and n are whole numbers less than or equal to 4.
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Abstract
The present invention provides a method of limiting the presence of a microorganism by contacting the microorganism with polymer-bound metal-containing compositions. The compositions include metal-containing compounds that may be prepared by reacting or polymerizing metal-containing monomers. The microorganism may be present in a liquid that is contacted with the polymer-bound metal-containing composition. Alternatively, the microorganism may be present in a solid that is contacted with the polymer-bound metal-containing composition.
25 Citations
29 Claims
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1. A method for limiting the presence of a microorganism, the method comprising contacting the microorganism with a polymer-bound metal-containing composition comprising a compound having the following formula:
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wherein; Z1 and Z2 each independently represent an arene nucleus, which has from 5 to 14 ring atoms;
G1 and G2 each independently represent a metal ligating group such that G1 and G2 may be contained within or pendant from at least one of Z1 and Z2;
R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkyl- or aryl sulfonyl group, an alkyl- or aryl sulfoxyl group, an aryloxyl group, a hydroxyl group, a thioarrido, a carbamoyl group, a sulfamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group;
L1 represents a nitrogen heterocycle substituted with R1 or R2 or both R1 and R2;
R1 and R2 each independently represent a polymer-bound group, a hydrogen, a halogen atom, an alkyl group, a vinyl group, a hydroxyalkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, an alkylthio group, an alkylamino group, an alkoxycarbonyl group, an acyloxy group, an alylsulfonyl group, an alkylsulfoxyl group, an alkylcarbamoyl group, an alkylsulfamoyl group, a formyl group, an acyl group, a silyl group, or a sulfoalkoxy group;
wherein at least one of R1 and R2 represents a polymer-bound group;
L2 represents a monodentate or polydentate ligand;
X represents nitrogen or a retained group;
M represents a platinum or palladium atom; and
k, m, and n are whole numbers less than or equal to 4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 28, 29)
wherein; R1 and R2 each independently represent H or a polymer-bound group, wherein at least one of R1 and R2 represents a polymer-bound group; and
X represents nitrogen or a methine group.
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4. The method of claim 3 wherein R1 represents a polymer-bound group comprising a polymer selected from the group consisting of vinyl polymers, vinyl copolymers, and polyurethanes;
- R2 represents H, and X represents nitrogen or a methine group.
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5. The method of claim 1 wherein the microorganism is a virus.
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6. The method of claim 5 wherein the virus is an enveloped virus.
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7. The method of claim 5 wherein the virus is HIV.
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8. The method of claim 5 wherein the virus is a member of the Herpes virus group.
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9. The method of claim 5 wherein the virus is an Influenza virus.
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10. The method of claim 1 wherein the microorganism is a bacterium.
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11. The method of claim 10 wherein the bacterium is a grain-positive bacterium.
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12. The method of claim 11 wherein the bacterium is an antibiotic-resistant gram-positive bacterium.
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13. The method of claim 10 wherein the bacterium is a gram-negative bacterium.
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14. The method of claim 13 wherein the bacterium is an antibiotic-resistant gram-negative bacterium.
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15. The method of claim 1 wherein the microorganism is a fungus.
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16. The method of claim 15 wherein the fungus is a yeast.
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17. The method of claim 1 wherein replication of the microorganism is inhibited by contacting the microorganism with the polymer-bound metal-containing composition.
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18. The method of claim 1 wherein the microorganism is killed by the contacting the microorganism with the polymer-bound metal-containing composition.
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19. The method of claim 1 wherein the microorganism is present in a liquid that is contacted with the polymer-bound metal-containing composition.
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20. The method of claim 1 wherein the microorganism is present in a solid that is contacted with the polymer-bound metal-containing composition.
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21. The method of claim 1 wherein the composition further comprises at least one other antimicrobial compound.
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22. The method of claim 1 wherein n is a whole number less than or equal to 2.
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28. The method of claim 3 wherein R1 represents a thermoplastic polymer-bound group;
- R2 represents H, and X represents nitrogen or a methine group.
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29. The method of claim 3 wherein R1 represents a polyolefin polymer-bound group;
- R2 represents H, and X represents nitrogen or a methine group.
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23. A polymer-bound metal-containing compound of the following formula:
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wherein; R1 and R2 each independently represent H or a polyurethane-bound group, wherein at least one of R1 and R2 represents a polyurethane-bound group;
X represents nitrogen or a methine group; and
M represents a platinum or palladium atom. - View Dependent Claims (24)
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25. A method of preparing a polymer-bound metal-containing compound of the following formula:
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wherein; R1 and R2 for the polymer-bound metal-containing compound each independently represent H or a polymer-bound group, wherein at least one of R1 and R2 for the polymer-bound metal-containing compound represents a polymer-bound group;
X represents nitrogen or a methine group; and
M represents a platinum or palladium atom;
the method comprising reacting a prepolymer or polymer with a metal-containing monomer of the following formula;
wherein; R1 and R2 for the monomer each independently represent H or CH2OH, wherein at least one of R1 and R2 for the monomer represents CH2OH;
X represents nitrogen or a methine group; and
M represents a platinum or palladium atom. - View Dependent Claims (26, 27)
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Specification
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Current Assignee3M Innovative Properties Company (3M Company)
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Original Assignee3M Innovative Properties Company (3M Company)
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InventorsMudalige, Chandrika D., Brandys, Frank A., Landgrebe, Kevin D., Cuny, Gregory D., Sengupta, Ashok, Smith, Terrance P., Hastings, David J.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)FUBARA, BLESSING M
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Application NumberUS09/611,346Time in Patent Office768 DaysField of Search424/78.08, 424/406, 514/184, 540/202, 540/203US Class Current424/78.08CPC Class CodesA61L 2/16 using chemical substancesA61L 2/238 Metals or alloys, e.g. olig...A61P 31/04 Antibacterial agentsA61P 31/10 AntimycoticsA61P 31/12 AntiviralsA61P 31/16 for influenza or rhinovirusesA61P 31/18 for HIVA61P 31/22 for herpes viruses
