Method for treatment of sleep apneas
First Claim
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1. A method for treatment of sleep apneas comprising administration of a therapeutically effective amount of a Formula I azapirone compound or a pharmaceutically effective acid addition salt thereof to a patient in need of such treatment;
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whereinZ is a member selected from the group consisting of
with the dotted and solid line representing either a single or a double chemical bond;
A being selected from the group consisting of O, CH2, CH2CH2 and CH═
CH;
R3 and R4 being independently selected from hydrogen and C1-4 alkyl or R3 and R4 can be taken together as a butanediyl or pentanediyl chain; and
R1 and R2 are either taken together asor R1 is hydrogen and R2 is
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Abstract
Certain azapirone compounds and their pharmaceutically acceptable salts are useful in the treatment of sleep apneas.
54 Citations
13 Claims
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1. A method for treatment of sleep apneas comprising administration of a therapeutically effective amount of a Formula I azapirone compound or a pharmaceutically effective acid addition salt thereof to a patient in need of such treatment;
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wherein Z is a member selected from the group consisting of
with the dotted and solid line representing either a single or a double chemical bond;
A being selected from the group consisting of O, CH2, CH2CH2 and CH═
CH;
R3 and R4 being independently selected from hydrogen and C1-4 alkyl or R3 and R4 can be taken together as a butanediyl or pentanediyl chain; and
R1 and R2 are either taken together asor R1 is hydrogen and R2 is - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification
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Current AssigneeBristol-Myers Squibb Company, Leland Stanford Junior University (Stanford University)
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Original AssigneeLeland Stanford Junior University (Stanford University)
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InventorsRosekind, Mark R., Schwimmer, Jeffrey L., Dement, William C.
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Primary Examiner(s)Criares, Theodore J.
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Application NumberUS07/695,325Time in Patent Office4,120 DaysField of Search514/252, 514/278, 514/923, 514/252.1, 514/252.12, 514/252.14, 514/252.18, 514/253.01, 514/253.12, 514/253.13US Class Current514/252.1CPC Class CodesA61K 31/435 having six-membered rings w...A61K 31/505 Pyrimidines; Hydrogenated p...
