Method and system for detecting cardiac depolarization

• US 6,434,417 B1
• Filed: 03/28/2000
• Issued: 08/13/2002
• Est. Priority Date: 03/28/2000
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Lovett, Eric G.
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US09/535,872
• Time in Patent Office: 868 Days
• Field of Search: 600/509, 600/515, 600/521, 128/901, 607/1-2, 607/4-5, 607/7, 607/9, 607/25-26
• US Class Current: 600/509
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A system and method for detection of specific cardiac depolarization events, such as atrial and ventricular beats. Cardiac electrical activity is sensed to generate a sense signal that is decomposed into components by orthogonal filters. Statistical features are extracted from the components and analyzed to detect a specific event. In one embodiment, the sense signal is decomposed into frequency components by bandpass filtering. The design of the bandpass filters is such that the frequency components can be analyzed to determine whether they match the frequency components of a template signal corresponding to the specific cardiac depolarization event.

Claims

1. A system for detecting a specific cardiac signal corresponding to a template signal, comprising:

a sensing channel for sensing cardiac electrical activity and outputting a sense signal in accordance therewith;

a first bank of bandpass filters for decomposing the sense signal into multiple frequency components, wherein the bandpass filters are selected with passbands corresponding to frequency components of the template signal;

a differentiator for extracting a derivative signal from each of the multiple frequency components of the sense signal;

an amplitude demodulator for detecting an envelope signal from each of the derivative signals; and

,

a multiplier for multiplying the envelope signals and outputting a composite signal in accordance therewith, the composite signal representing a correspondence between the sensed signal and the template signal.

2. The system of claim 1 wherein the sense signal is digitized, and the filter bank and amplitude demodulator are implemented digitally by a processor.

3. The system of claim 1 wherein the amplitude demodulator comprises a full-wave rectifier and low-pass filter.

4. The system of claim 1 wherein the sensing channel is configured to detect ventricular depolarizations.

5. The system of claim 1 wherein the sensing channel is configured to detect atrial depolarizations.

6. The system of claim 1 wherein the passbands of the bandpass filter bank are contiguous divisions of a frequency range between approximately 10 and 50 Hz to represent the frequency components of a cardiac depolarization.

7. The system of claim 1 wherein the passbands of the bandpass filter bank are contiguous divisions of a frequency range between approximately 0 and 50 Hz to represent the frequency components of a cardiac depolarization.

8. The system of claim 6 further comprising a second filter bank with passbands dividing a lower frequency range than the frequency range of the first filter bank, wherein the outputs of the second filter bank are multiplied together to form a second composite signal.

9. The system of claim 8 further comprising a comparator for comparing the first and second composite signals to detect ectopic beats.

15. A processor-executable storage medium containing code for processing a sense signal in accordance with the method as set forth in claim 1.

16. The method of claim 1 wherein the biological depolarization. event is a cardiac depolarization event.

17. The method of claim 16 wherein the amplitude demodulation is performed by full-wave rectification and low-pass filtering.

18. The method of claim 16 wherein the specific depolarization event detected is a ventricular depolarization.

19. The method of claim 16 wherein the specific depolarization event detected is a atrial depolarization.

20. The method of claim 16 wherein the passbands of the bandpass filter bank are contiguous divisions of a frequency range between approximately 0 and 50 Hz to represent the frequency components of a specific cardiac depolarization event.

21. The method of claim 16 wherein the passbands of the bandpass filter bank are contiguous divisions of a frequency range between approximately 10 and 50 Hz to represent the frequency components of a specific cardiac depolarization event.

22. The method of claim 21 comprising:

filtering the sense signal with a second filter bank having passbands that pass a lower frequency range than the frequency range of the first filter bank; and

,

multiplying the outputs of the second filter bank together to form a second composite signal.

23. The method of claim 22 further comprising comparing the first and second composite signals to detect ectopic beats.

24. The method of claim 16 wherein the filtering, differentiation, and amplitude demodulation are performed digitally by a processor.

25. The method of claim 24 wherein the bandpass filtering is performed by combining the outputs of a plurality of moving average filters.

10. A method for detecting a specific biological depolarization event, comprising:

sensing bioelectrical activity to generate a sense signal in accordance therewith;

filtering the sense signal with a first bank of orthogonal filters to thereby decompose the sense signal into linearly independent components;

synchronously extracting a statistical feature from each component of the sense signal; and

,

comparing the extracted features with features representing linearly independent components of a template signal corresponding to the specific depolarization event.

11. The method of claim 10 wherein the bank of orthogonal filters comprises a bank of bandpass filters for decomposing the sense signal into multiple frequency components, and wherein the bandpass filters are selected with passbands corresponding to frequency components of the template signal, the method further comprising:

extracting derivative signals from the multiple frequency components of the sense signal;

amplitude demodulating the derivative signals to detect an envelope signal from each of the derivative signals;

multiplying the envelope signals to thereby generate a composite signal representing detection of the specific depolarization event.

12. The method of claim 10 wherein the statistical features are extracted from the sense signal components in synchronization with a trigger signal.

13. The method of claim 12 wherein the trigger signal is a sensed cardiac signal.

14. A method for detecting a specific biological depolarization event, comprising:

sensing bioelectrical activity to generate a sense signal in accordance therewith;

filtering the sense signal with a first bank of bandpass filters to thereby decompose the sense signal into multiple frequency components, wherein the bandpass filters are selected with passbands corresponding to frequency components of a template signal representing the specific depolarization event;

extracting derivative signals from the multiple frequency components of the sense signal;

amplitude demodulating the derivative signals to detect an envelope signal from each of the derivative signals;

multiplying the envelope signals to thereby generate a composite signal representing detection of the specific depolarization event.